Thalamic synchrony and the adaptive gating of information flow to cortex.
Thalamic synchrony and the adaptive gating of information flow to cortex.
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DOI：
10.1038/nn.2670
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发表时间：
2010-12
影响因子：
25
通讯作者：
Stanley, Garrett B.
中科院分区：
文献类型：
--
作者：
Wang, Qi;Webber, Roxanna M.;Stanley, Garrett B.
虽然长期以来人们一直认为感觉适应有助于增强感觉通路中的信息流，但神经基础仍然难以捉摸。同时在麻醉大鼠丘脑和皮层的单单位录音显示，适应差异影响丘脑和皮层的方式，从根本上改变了有关触须运动传递的信息的性质。利用一个理想的观察者的皮层活动，在检测触须偏转的性能降低与适应，而在不同速度的触须偏转之间的区别的性能增强，在丘脑中没有观察到的趋势。然而，对同时记录的丘脑神经元的分析确实揭示了丘脑同步性的一种类似的适应性变化，这种变化反映了皮层的反应。使用实验测量的丘脑输入的集成和消防模型再现所观察到的转换。这里的结果表明，编码策略的转变与适应，直接控制信息传递到皮层，这可能有影响的编码速度签名的纹理。
Although it has long been posited that sensory adaptation serves to enhance information flow in sensory pathways, the neural basis remains elusive. Simultaneous single–unit recordings in the thalamus and cortex in anesthetized rats reveal that adaptation differentially influences thalamus and cortex in a manner that fundamentally changes the nature of information conveyed about vibrissae motion. Utilizing an ideal observer of cortical activity, performance in detecting vibrissa deflections degrades with adaptation, while performance in discriminating between vibrissa deflections of different velocities is enhanced, a trend not observed in thalamus. Analysis of simultaneously recorded thalamic neurons does reveal, however, an analogous adaptive change in thalamic synchrony that mirrors the cortical response. An integrate–and–fire model using experimentally measured thalamic input reproduces the observed transformations. The results here suggest a shift in coding strategy with adaptation that directly controls information relayed to cortex, which could have implications for encoding velocity signatures of textures.
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