How Does G-CSF Act on the Kidney during Acute Tubular Injury?
How Does G-CSF Act on the Kidney during Acute Tubular Injury?
复制标题
DOI：
10.1159/000094962
复制
发表时间：
2006-08
影响因子：
--
通讯作者：
M. Nishida;K. Hamaoka
中科院分区：
文献类型：
--
作者：
M. Nishida;K. Hamaoka
近年来，干细胞研究发现骨髓细胞具有多谱系可塑性，造血干细胞对包括肾脏在内的受损器官的再生也有重要作用。这些研究结果表明，使用粒细胞集落刺激因子（G-CSF）作为一种治疗选择，以再生受损器官的可能性。最近，在急性肾衰竭小鼠模型中报道了几项关于G-CSF对肾功能影响的研究。这一系列的实验提供了有关肾损伤患者治疗的潜在重要信息。本文综述了G-CSF对肾脏的可能作用，特别是在毒性或缺血性损伤引起的急性肾小管损伤中。
Recent findings in stem cell research have demonstrated multi-lineage plasticity of bone marrow cells, and also the contribution of hematopoietic bone marrow stem cells to the regeneration of injured organs including the kidney. These findings suggested the possibility of the use of granulocyte colony-stimulating factor (G-CSF) as a therapeutic option to regenerate injured organs. Recently, several studies regarding the effect of G-CSF on renal function have been reported in mouse models of acute renal failure. This series of experiments provided potentially important information regarding the treatment of patients with renal injury. This review summarizes the possible actions of G-CSF on the kidney, especially during acute tubular injury caused by toxic or ischemic insults.