Plasticity in brain sexuality is revealed by the rapid actions of steroid hormones
Plasticity in brain sexuality is revealed by the rapid actions of steroid hormones
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DOI：
10.1523/jneurosci.4282-06.2007
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发表时间：
2007-01-31
影响因子：
5.3
通讯作者：
Bass, Andrew H.
中科院分区：
文献类型：
--
作者：
Remage-Healey, Luke;Bass, Andrew H.
不同的类固醇激素谱可以塑造男性与女性神经表型的发展，但它们是否也决定了短期行为的神经生理模式的差异尚不清楚。现在，我们表明，类固醇激素特异性调制的发声模式发生器（VPG）之间的分歧在硬骨鱼的生殖形态。只有I型男性海军军官候补生声学法院的女性，而II型男性窃取受精从I型男性，像女性一样，只产生竞争的呼吁。雄激素11-酮睾酮（11 kT），而不是睾酮（T），迅速（5分钟内）增加I型VPG输出。如图所示，T（而不是11 kT）迅速增加II型男性和女性的VPG输出，这与II型男性和女性（T）与I型（11 kT）相比主要的循环雄激素一致。受体和酶拮抗剂揭示了一个意想不到的分歧，雄激素与雌激素依赖的机制，分别在II型男性与女性。皮质醇，主要的循环糖皮质激素，也有不同的行动：抑制与增加VPG输出，分别在II型男性和女性与I型。总之，类固醇对VPG活性的快速作用与性腺表型无关（II型男性和女性之间的趋同），而受体介导的雄激素作用机制可通过性腺表型预测（两种男性形态对雄激素受体阻断敏感，而女性则不敏感）。神经内分泌特征的可比组合可以解释在硬骨鱼类和一般脊椎动物中广泛分布的性内行为表型。此外，基本的组织/激活原则，预测类固醇依赖的表达“男性”和“女性”现在可能包括快速类固醇行动的神经生理模式的行为。
Divergent steroid hormone profiles can shape the development of male versus female neural phenotypes, but whether they also determine differences in the short-term, neurophysiological patterning of behavior is unknown. We now show that steroid hormone-specific modulation of a vocal pattern generator (VPG) diverges between reproductive morphs in a teleost fish. Only type I male midshipman acoustically court females, whereas type II males steal fertilizations from type I males and, like females, generate only agonistic calls. The androgen 11-ketotestosterone (11kT), but not testosterone (T), rapidly (within 5 min) increases type I VPG output. As now shown, T, but not 11kT, rapidly increases VPG output in type II males and females, consistent with the predominant circulating androgen in type II males and females (T) versus type Is (11kT). Receptor and enzyme antagonists reveal an unexpected divergence in androgen-versus estrogen-dependent mechanisms in, respectively, type II males versus females. Cortisol, the main circulating glucocorticoid, also has divergent actions: suppressing versus increasing VPG output in, respectively, type II males and females versus type Is. In summary, rapid steroid action on VPG activity is uncoupled from gonadal phenotype (convergent between type II males and females), whereas the receptor-mediated mechanisms of androgen action are predicted by gonadal phenotype (both male morphs are sensitive to androgen receptor blockade, whereas females are not). A comparable mix of neuroendocrine traits may explain the widespread distribution of intrasexual behavioral phenotypes among teleosts and vertebrates in general. Moreover, the fundamental organization/activation principles that predict the steroid-dependent expression of "maleness" and "femaleness" may now include rapid steroid actions on the neurophysiological patterning of behavior.