Data mining and frequency analysis for licorice as a "Two-Face" herb in Chinese Formulae based on Chinese Formulae Database
Data mining and frequency analysis for licorice as a "Two-Face" herb in Chinese Formulae based on Chinese Formulae Database
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DOI：
10.1016/j.phymed.2014.07.006
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发表时间：
2014-09-25
期刊：
影响因子：
7.9
通讯作者：
Tang, Yuping
中科院分区：
文献类型：
--
作者：
Guo, Jianming;Shang, Erxin;Tang, Yuping
甘草为甘草菲施的根。或光果甘草（Corrhiza glabra L.）甘草在中医学中被称为“国医大师”，具有解毒/增强功效和诱导/增强毒性的矛盾作用。因此，本文称甘草为“双面药”。本研究以《中国方剂数据库》中的96，000余首方剂为研究对象，运用数据挖掘和频数分析的方法，探讨中药“两面派”的矛盾作用及其应用前景。使用Microsoft SQL Server 2000分析频率和处方模式。数据挖掘方法利用频繁项集分析所选方药中组成药物的规律和配伍规律，结果表明甘草方剂数据库中最常用的药物是黄芪，其他常用药物包括黄芪、甘草（当归）、人参（人参）等有毒草药，如附子（附子），半夏、朱砂是甘草配伍最多的三种药物。人参、茯苓、当归是最常与甘草配伍的3种无毒药物。甘草很少与海藻、大蓟、甘遂、芫花等配伍使用，证明了中医理论中甘草与这些药的矛盾作用，揭示了甘草与甘草配伍使用的规律。本文所报道的甘草配伍规律和特殊配伍规律，对临床科学用药具有一定的指导意义。需要进一步的药理和化学研究来评估这些中药的功效和组合模式。还应使用体外或体内模型研究这些处方的组合模式的机制是否存在相加、协同或拮抗作用。(C)2014 Elsevier GmbH. All rights reserved.
Liquorice is the root of Glycyrrhiza uralensis Fisch. or Glycyrrhiza glabra L, Leguminosae. Licorice is described as 'National Venerable Master' in Chinese medicine and plays paradoxical roles, i.e. detoxification/strengthen efficacy and inducing/enhancing toxicity. Therefore, licorice was called "Two-Face" herb in this paper. The aim of this study is to discuss the paradoxical roles and the perspective usage of this "Two-Face" herb using data mining and frequency analysis.More than 96,000 prescriptions from Chinese Formulae Database were selected. The frequency and the prescription patterns were analyzed using Microsoft SQL Server 2000. Data mining methods (frequent itemsets) were used to analyze the regular patterns and compatibility laws of the constituent herbs in the selected prescriptions.The result showed that licorice (Radix glycyrrhizae) was the most frequently used herb in Chinese Formulae Database, other frequently used herbs including Radix Angelicae Sinensis (Dang gui), Radix et rhizoma ginseng (Ren shen), etc. Toxic herbs such as Radix aconiti lateralis praeparata (Fu zi), Rhizoma pinelliae (Ban xia) and Cinnabaris (Zhu sha) are top 3 herbs that most frequently used in combination with licorice. Radix et rhizoma ginseng (Ren shen), Poria (Fu ling), Radix Angelicae Sinensis (Dang gui) are top 3 nontoxic herbs that most frequently used in combination with licorice. Moreover, Licorice was seldom used with sargassum (Hai Zao), Herba Cirsii Japonici (Da Ji), Euphorbia kansui (Gan Sui) and Flos genkwa (Yuan Hua), which proved the description of contradictory effect of Radix glycyrrhizae and these herbs as recorded in Chinese medicine theory.This study showed the principle pattern of Chinese herbal drugs used in combination with licorice or not. The principle patterns and special compatibility laws reported here could be useful and instructive for scientific usage of licorice in clinic application. Further pharmacological and chemical researches are needed to evaluate the efficacy and the combination pattern of these Chinese herbs. The mechanism of the combination pattern of these prescriptions should also be investigated whether additive, synergistic or antagonistic effect exist using in vitro or in vivo models. (C) 2014 Elsevier GmbH. All rights reserved.