Susceptibilities of simian immunodeficiency virus to protease inhibitors
Susceptibilities of simian immunodeficiency virus to protease inhibitors
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DOI：
10.1128/aac.47.5.1756-1759.2003
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发表时间：
2003-05-01
影响因子：
4.9
通讯作者：
North, TW
中科院分区：
文献类型：
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作者：
Giuffre, AC;Higgins, J;North, TW
我们用海拉H1-JC进行局灶性感染试验。37个细胞直接比较猴免疫缺陷病毒（SIV）和人类免疫缺陷病毒1型（HIV-1）对蛋白酶抑制剂的敏感性。茚地那韦、沙奎那韦和利托那韦对SIVmac239有抑制作用，50%有效浓度（平均值+/-标准差）分别为39+/-8、55+/-3和13+/-5 nM。相应的抑制值分别为66+/-4 nM、47+/-10 nM和25+/-14 nM。
We used a focal infectivity assay with HeLa H1-JC.37 cells to directly compare susceptibilities of simian immunodeficiency virus (SIV) and human immunodeficiency virus type 1 (HIV-1) to protease inhibitors. SIVmac239 was inhibited by indinavir, saquinavir, and ritonavir, with 50% effective concentrations (means +/- standard deviations) of 39+/-8, 55+/-3, and 13+/-5 nM, respectively. The corresponding values for inhibition of HIV-1 were 66+/-4, 47+/-10, and 25+/-14 nM, respectively.