Patterns of co-morbidity with anxiety disorders in Chinese women with recurrent major depression.
Patterns of co-morbidity with anxiety disorders in Chinese women with recurrent major depression.
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DOI：
10.1017/s003329171100273x
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发表时间：
2012-06
影响因子：
6.9
通讯作者：
Zhang, Z.
中科院分区：
文献类型：
--
作者：
Li, Y.;Shi, S.;Yang, F.;Gao, J.;Li, Youhui;Tao, M.;Wang, G.;Zhang, K.;Gao, C.;Liu, L.;Li, Kan;Li, Keqing;Liu, Y.;Wang, Xumei;Zhang, J.;Lv, L.;Wang, Xueyi;Chen, Q.;Hu, J.;Sun, L.;Shi, J.;Chen, Y.;Xie, D.;Flint, J.;Kendler, K. S.;Zhang, Z.
在欧洲和美国进行的研究表明，重度抑郁症（MDD）和焦虑症之间的共病与各种MDD相关特征相关，包括临床症状、家族聚集程度和社会经济状况。然而，很少有研究调查这些关联模式是否在不同的共病焦虑症中有所不同。在这里，我们使用一个大的中国女性抑郁症复发队列，研究共病焦虑障碍的患病率和相关的临床特征。在CONVERGE研究中，共确定了1970名中国女性MDD患者，伴有或不伴有7种共病焦虑障碍[包括广泛性焦虑障碍（GAD）、惊恐障碍和5种恐怖症亚型]。广义线性模型被用来模拟共病焦虑症和各种MDD特征之间的关联。任何类型的共病焦虑障碍的终生患病率为60.2%。惊恐和社交恐惧症显著预测MDD家族史的增加。GAD和动物恐惧症分别预测MDD的早期发作和MDD发作次数的增加。惊恐和广泛性焦虑症预测了更多的DSM-IV诊断标准。GAD和血伤恐怖与自杀未遂均显著相关，但作用相反。所有七种共病焦虑症都预示着更高的神经质。MDD和焦虑之间的共病模式与美国和欧洲研究的结果一致;当检测与各种MDD特征的相关性时，7种共病焦虑障碍是异质性的。
Studies conducted in Europe and the USA have shown that co-morbidity between major depressive disorder (MDD) and anxiety disorders is associated with various MDD-related features, including clinical symptoms, degree of familial aggregation and socio-economic status. However, few studies have investigated whether these patterns of association vary across different co-morbid anxiety disorders. Here, using a large cohort of Chinese women with recurrent MDD, we examine the prevalence and associated clinical features of co-morbid anxiety disorders. A total of 1970 female Chinese MDD patients with or without seven co-morbid anxiety disorders [including generalized anxiety disorder (GAD), panic disorder, and five phobia subtypes] were ascertained in the CONVERGE study. Generalized linear models were used to model association between co-morbid anxiety disorders and various MDD features. The lifetime prevalence rate for any type of co-morbid anxiety disorder is 60.2%. Panic and social phobia significantly predict an increased family history of MDD. GAD and animal phobia predict an earlier onset of MDD and a higher number of MDD episodes, respectively. Panic and GAD predict a higher number of DSM-IV diagnostic criteria. GAD and blood-injury phobia are both significantly associated with suicidal attempt with opposite effects. All seven co-morbid anxiety disorders predict higher neuroticism. Patterns of co-morbidity between MDD and anxiety are consistent with findings from the US and European studies; the seven co-morbid anxiety disorders are heterogeneous when tested for association with various MDD features.