Association of serum uric acid with subsequent arterial stiffness and renal function in normotensive subjects
Association of serum uric acid with subsequent arterial stiffness and renal function in normotensive subjects
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DOI：
10.1038/hr.2017.10
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发表时间：
2017-06-01
影响因子：
5.4
通讯作者：
Arita, Mikio
中科院分区：
文献类型：
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作者：
Nagano, Shiori;Takahashi, Maasa;Arita, Mikio
血清尿酸(SUA)不仅与痛风的风险增加有关，而且与心血管疾病的风险增加有关。本研究旨在纵向评估血尿酸水平对正常血压受试者人群样本的肾功能和动脉僵硬的影响。受试者在2002年完成了基线的健康检查，并在2011年或2012年的跟踪期结束时完成了健康检查。共有407名血压正常的受试者(男171人，女236人)，年龄26-66岁。测量血压(BP)、臂踝脉搏波速度(BaPWV)、中心压、内中膜厚度、血尿酸水平和估计的肾小球滤过率(EGFR)。我们根据基线时的血尿酸四分位数将受试者分为四个亚组，并在随访后比较肾功能和动脉硬度。截止值分别为3.6、4.4、5.6和9.6 mg dl(-1)。与BaPWV(Q1,1324；Q2,1457；Q3,1442；Q4,1489 cm S(-1))、收缩压(Q1,110.9；Q2,110.1；Q3,112.8；Q4)相关的血尿酸水平。116.1毫米汞柱)和EGFR(P代表趋势
Serum uric acid (SUA) is correlated with an increased risk of not only gout but also cardiovascular diseases. The present study aimed to longitudinally evaluate the effects of SUA level on renal function and arterial stiffness in a population-based sample of normotensive subjects. The subjects completed a health checkup in 2002 at baseline and in 2011 or 2012 at the end of the follow-up period. A total of 407 normotensive subjects (171 men and 236 women) aged 26-66 years were enrolled in this study. We measured blood pressure (BP), brachial-ankle pulse wave velocity (baPWV), central BP, intima-media thickness, SUA level and estimated glomerular filtration rate (eGFR). We divided the subjects into four subgroups according to the SUA quartile at baseline and compared renal function and arterial stiffness after the follow-up. The cutoff values were 3.6, 4.4, 5.6 and 9.6 mg dl(-1). The SUA levels associated with baPWV (Q1, 1324; Q2, 1457; Q3, 1442; Q4, 1489 cm s(-1)), systolic BP (SBP) (Q1, 110.9; Q2, 110.1; Q3, 112.8; Q4. 116.1 mm Hg) and eGFR (P for trend