Molecular characterization of genetic loci required for secretion of exoproducts in Burkholderia pseudomallei
Molecular characterization of genetic loci required for secretion of exoproducts in Burkholderia pseudomallei
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DOI：
10.1128/jb.181.15.4661-4664.1999
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发表时间：
1999-08-01
影响因子：
3.2
通讯作者：
Woods, DE
中科院分区：
文献类型：
--
作者：
DeShazer, D;Brett, PJ;Woods, DE
以往的研究表明，类鼻疽伯克霍尔德菌分泌蛋白酶、脂肪酶和磷脂酶C（PLC）到胞外，但其分泌机制及其在致病中的作用尚未阐明。在这项研究中，我们分离和表征29转座子突变体不能分泌蛋白酶，脂肪酶，和PLC。
Previous studies have demonstrated thatBurkholderia pseudomalleisecretes protease, lipase, and phospholipase C (PLC) into the extracellular milieu, but their mechanisms of secretion and roles in pathogenesis have not been elucidated. In this study, we isolated and characterized 29 transposon mutants unable to secrete protease, lipase, and PLC.