The origins of genome complexity
The origins of genome complexity
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DOI：
10.1126/science.1089370
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发表时间：
2003-11-21
期刊：
影响因子：
56.9
通讯作者：
Conery, JS
中科院分区：
文献类型：
--
作者：
Lynch, M;Conery, JS
来自不同系统发育谱系的完整基因组序列揭示了从原核生物到多细胞真核生物基因组复杂性的显着增加。这些变化包括由于重复基因的保留而导致的基因数量的逐渐增加，以及剪接体内含子和移动的遗传元件丰度的更突然的增加。我们认为，许多这些modi。阳离子被动地出现，以应对长期人口规模的减少，伴随着生物体的大小增加。根据这一模型，真核生物基因组的大部分重组都是由非适应性过程引发的，这反过来又为自然选择导致的表型复杂性的二次进化提供了新的底物。原核生物巨大的长期有效种群规模可能会对复杂基因组和形态的进化构成实质性障碍。
Complete genomic sequences from diverse phylogenetic lineages reveal notable increases in genome complexity from prokaryotes to multicellular eukaryotes. The changes include gradual increases in gene number, resulting from the retention of duplicate genes, and more abrupt increases in the abundance of spliceosomal introns and mobile genetic elements. We argue that many of these modi. cations emerged passively in response to the long-term population-size reductions that accompanied increases in organism size. According to this model, much of the restructuring of eukaryotic genomes was initiated by nonadaptive processes, and this in turn provided novel substrates for the secondary evolution of phenotypic complexity by natural selection. The enormous long-term effective population sizes of prokaryotes may impose a substantial barrier to the evolution of complex genomes and morphologies.