Batch production of micron size particles from poly(ethylene glycol) using supercritical CO2 as a processing solvent
Batch production of micron size particles from poly(ethylene glycol) using supercritical CO2 as a processing solvent
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使用超临界二氧化碳作为加工溶剂，从聚乙二醇中批量生产微米级颗粒
DOI：
10.1016/j.ces.2006.04.034
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发表时间：
2007
影响因子：
4.7
通讯作者：
L. Janssen
中科院分区：
文献类型：
--
作者：
S. Nalawade;F. Picchioni;L. Janssen
在聚合物加工中使用超临界二氧化碳（CO2）作为溶剂的主要优点是由于溶解的CO2而增加了聚合物的自由体积，这导致粘度显著降低。这允许在低温下喷涂聚合物熔体以产生微米尺寸的颗粒。我们已经使用超临界CO2作为溶剂，用于从不同分子量的聚（乙二醇）（PEG）生成颗粒。由于PEG是亲水性化合物，因此它是用于包封药物的最常用的聚合物。具有不同性质的PEG颗粒可以允许对药物的释放保持良好的控制。已经可以通过改变各种工艺参数如分子量、温度、压力和喷嘴直径来生产具有不同尺寸、尺寸分布、孔隙率和形状的颗粒。流动和凝固模型已被应用，以便有一个理论上的洞察不同的参数的作用。
The major advantage of using supercritical carbon dioxide (CO2) as a solvent in polymer processing is an enhancement in the free volume of a polymer due to dissolved CO2, which causes a considerable reduction in the viscosity. This allows spraying the polymer melt at low temperatures to produce micron size particles. We have used supercritical CO2as a solvent for the generation of particles from poly(ethylene glycol) (PEG) of different molecular weights. Since PEG is a hydrophilic compound, it is a most commonly used polymer for encapsulating a drug. PEG particles with different properties may allow keeping a good control over the release of the drug. It has been possible to produce particles with different size, size distribution, porosity and shape by varying various process parameters such as molecular weight, temperature, pressure and nozzle diameter. A flow and a solidification model have been applied in order to have a theoretical insight into the role of different parameters.