A 7 minute neurocognitive screening battery highly sensitive to Alzheimer's disease
A 7 minute neurocognitive screening battery highly sensitive to Alzheimer's disease
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DOI：
10.1001/archneur.55.3.349
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发表时间：
1998-03-01
影响因子：
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通讯作者：
Pendlebury, WW
中科院分区：
文献类型：
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作者：
Solomon, PR;Hirschoff, A;Pendlebury, WW
目的：确定由4项简短测试组成的快速神经认知筛查组合的有效性和可靠性（增强的线索回忆、时间定向、言语流畅性和时钟绘制）来区分可能患有阿尔茨海默病（AD）的患者和健康对照受试者。连续60次转诊到位于本宁顿的佛蒙特州西南医疗中心的记忆障碍诊所，被诊断为可能患有AD的患者和60名年龄、性别分布和教育程度相当的社区志愿者。设计：评定者间和重测信度，AD患者和对照受试者在4项单独测试中的组间比较，并使用整套测试确定AD患者和对照受试者的痴呆概率。设置：门诊护理。主要结果测量：将7分钟筛查中痴呆的概率与通过检查和实验室研究建立的临床诊断标准进行比较。重测信度和评分者间信度（相关系数），给药时间。结果：平均给药时间为7分42秒。AD患者和对照组在所有4项单独测试中的平均得分均存在显著差异（对于每一项，P
Objective: To determine the validity and reliability of a rapidly administered neurocognitive screening battery consisting of 4 brief tests (Enhanced Cued Recall, Temporal Orientation, Verbal Fluency, and Clock Drawing) to distinguish between patients with probable Alzheimer's disease (AD) and healthy control subjects.Subjects: Sixty successive referrals to the Memory Disorders Clinic at Southwestern Vermont Medical Center, Bennington, who were diagnosed as having probable AD and 60 community-dwelling volunteers of comparable age, sex distribution, and education.Design: Interrater and test-retest reliability, intergroup comparisons between patients with AD and control subjects on the 4 individual tests, and determination of probability of dementia for patients with AD and control subjects using the entire battery of tests.Setting: Outpatient care.Main Outcome Measure: Comparison of the probability of dementia on the 7 Minute Screen with the criterion standard of clinical diagnosis established by examination and laboratory studies.Secondary Outcome Measures: Test-retest and interrater reliability (correlation coefficients), time for administration.Results: Mean time of administration was 7 minutes 42 seconds. Mean scores for patients with AD and control subjects on all 4 individual tests were significantly different (for each, P