The immune risk profile is associated with age and gender: findings from three Swedish population studies of individuals 20-100 years of age
The immune risk profile is associated with age and gender: findings from three Swedish population studies of individuals 20-100 years of age
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DOI：
10.1007/s10522-008-9138-6
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发表时间：
2008-10-01
期刊：
影响因子：
4.5
通讯作者：
Nilsson, Sven E.
中科院分区：
文献类型：
--
作者：
Wikby, Anders;Mansson, Ingrid A.;Nilsson, Sven E.
早期，我们确定了一个非常老的人，86-94岁的免疫风险概况（IRP），其特征是倒置的CD 4/CD 8比率，并与持续巨细胞病毒感染和CD 3 + CD 8 + CD 28-细胞的数量增加。在本研究中，我们纳入了年龄范围为20-79岁的基于人群的样本数据，以检查在整个成人寿命中CD 4/CD 8比率相对于年龄和性别倒置的个体的患病率。进行的免疫学监测包括分析亚群CD 3+、CD 3 + CD 4+和CD 3 + CD 8+以及CD 3 + CD 8 + CD 28+、CD 3 + CD 8 + CD 28-和CD 8 + CD 45 RA + CCR 7+中的T细胞数量。发现在整个成人寿命期间，CD 3+、CD 3 + CD 4+和CD 3 + CD 8+以及CD 8 + CD 45 RA + CCR 7+细胞的数量显著降低。值得注意的是，CD 4/CD 8比率倒置的个体的患病率从20-59岁年龄范围的约8%增加到60-94岁年龄范围的约16%。CD 4/CD 8比值倒置的个体的死亡率在60岁以上也显著增加。有趣的是，男性中CD 4/CD 8比值倒置的个体比例显著较高，而女性中CD 3 + CD 4+辅助细胞和CD 8 + CD 45 RA + CCR 7+幼稚细胞的数量以及CD 4/CD 8比值显著较高。这些结果强调了胸腺功能在IRP发展中的重要性，并可能部分解释了性别之间在寿命方面的差异。
Earlier we identified an Immune Risk Profile (IRP) of very old individuals, 86-94 years of age, characterised by an inverted CD4/CD8 ratio and associated with persistent cytomegalovirus infection and an increase in the numbers of CD3+CD8+CD28- cells. In the present study we included data from a population-based sample in the age range of 20-79 years to examine the prevalence of individuals with an inverted CD4/CD8 ratio relative to age and gender across the entire adult lifespan. Immunological monitoring that was conducted included analysis of the numbers of T-cells in the subsets CD3+, CD3+CD4+, and CD3+CD8+ as well as CD3+CD8+CD28+, CD3+CD8+CD28-, and CD8+CD45RA+CCR7+. There was found to be a significant lowering of the numbers of CD3+, CD3+CD4+, and CD3+CD8+, and of the CD8+CD45RA+CCR7+ cells across the adult life-span. Notably, the prevalence of individuals with an inverted CD4/CD8 ratio increased from about 8% in the age range of 20-59 years to about 16% in the age range of 60-94 years. The mortality rate in individuals with an inverted CD4/CD8 ratio also increased significantly above the age of 60. Interestingly, the proportion of individuals with an inverted CD4/CD8 ratio was found to be significantly higher in men, whereas the numbers of CD3+CD4+ helper and CD8+CD45RA+CCR7+ naive cells and the CD4/CD8 ratio were found to be significantly higher in women. These results highlight the importance of functioning of the thymus in the development of IRP and may partly account for the differences between sexes in terms of longevity.