Transmission characteristics of tuberculosis in the foreign-born and the Canadian-born populations of Alberta, Canada.
Transmission characteristics of tuberculosis in the foreign-born and the Canadian-born populations of Alberta, Canada.
复制标题
加拿大艾伯塔省外国出生和加拿大出生人群中结核病的传播特征。
DOI：
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发表时间：
2004
期刊：
影响因子：
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通讯作者：
R. Long
中科院分区：
文献类型：
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作者：
D. Kunimoto;K. Sutherland;K. Wooldrage;A. Fanning;L. Chui;J. Manfreda;R. Long
设置
1994-1998 年加拿大阿尔伯塔省所有通报的结核病病例。
目标
比较外国出生和加拿大出生病例中结核病的传播特征。
设计
使用 DNA 指纹识别（IS6110 限制性片段长度多态性和 spoligotyping）和阿尔伯塔省结核病登记处的患者信息进行回顾性分析。传播指数是通过计算单一来源病例产生的培养阳性肺部病例的平均数量来确定的。
结果
在750例活动性结核病病例中，437例（58.3%）是外国出生的。对 1994 年至 1998 年 5 年间所有 573 例培养阳性病例的结核分枝杆菌分离株进行的 DNA 指纹分析显示，与加拿大出生的非原住民 (28.8%) 和原住民 (44.7%) 分离株相比，外国出生的分离株 (9.8%) 的聚集性明显较少。男性的传播指数明显较高，≥65 岁的传播指数较低，原住民的传播指数较高。
结论
尽管在艾伯塔省，外国出生的结核病病例占大多数，但很少有结核病传染给其他外国出生或加拿大出生的人。结核病在原住民中的传播仍然是艾伯塔省的一个重大问题。
SETTING
All notified cases of tuberculosis in the province of Alberta, Canada, 1994-1998.
OBJECTIVE
To compare the transmission characteristics of tuberculosis among foreign-born and Canadian-born cases.
DESIGN
Retrospective analysis using DNA fingerprinting (IS6110 restriction fragment length polymorphism and spoligotyping) and patient information from the Alberta Tuberculosis Registry. Transmission indexes were determined by calculating the average number of culture-positive pulmonary cases generated by a single source case.
RESULTS
Of the 750 cases of active tuberculosis, 437 (58.3%) were in the foreign-born. DNA fingerprinting of Mycobacterium tuberculosis isolates from all 573 culture-positive cases over the 5 years from 1994 to 1998 showed that there was significantly less clustering among foreign-born isolates (9.8%) compared to Canadian-born non-Aboriginal (28.8%) and Aboriginal (44.7%) isolates. The transmission index was significantly higher for males, lower for those > or =65 years of age, and higher for Aboriginals.
CONCLUSION
Although cases of tuberculosis in the foreign-born constitute the majority in Alberta, there is little transmission to other foreign-born or to Canadian-born individuals. Transmission of tuberculosis among the Aboriginal population remains a significant problem in Alberta.