Acetylation goes global: the emergence of acetylation biology.
Acetylation goes global: the emergence of acetylation biology.
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DOI：
10.1126/scisignal.297pe76
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发表时间：
2009-11-17
影响因子：
7.3
通讯作者：
Yao TP
中科院分区：
文献类型：
--
作者：
Norris KL;Lee JY;Yao TP
自发现以来的前30年，可逆蛋白质乙酰化几乎完全在组蛋白修饰和基因转录的背景下进行了研究和理解。随着非组蛋白乙酰化蛋白和乙酰化修饰酶在细胞核外的细胞区室中的发现，可逆乙酰化的调节潜力在过去十年中逐渐被认识到。然而，蛋白质乙酰化参与复杂生物过程的范围仍然不确定。近年来，新技术的发展首次实现了在全蛋白质组水平上对乙酰组、乙酰化事件的鉴定和定量。这些努力揭示了乙酰基组的惊人复杂性，可能与磷酸化蛋白质组相媲美。这些新的研究揭示了蛋白质乙酰化的普遍存在和保守性，这表明了这种动态修饰的调节能力。全面乙酰组的建立将改变蛋白质乙酰化的格局，这是一个令人兴奋的研究前沿。
For the first 30 years since its discovery, reversible protein acetylation has been studied and understood almost exclusively in the context of histone modification and gene transcription. With the discovery of non–histone acetylated proteins and acetylation-modifying enzymes in cellular compartments outside the nucleus, the regulatory potential of reversible acetylation has slowly been recognized in the last decade. However, the scope of protein acetylation involvement in complex biological processes remains uncertain. The recent development of new technology has enabled, for the first time, the identification and quantification of the acetylome, acetylation events at the whole-proteome level. These efforts have uncovered a stunning complexity of the acetylome that potentially rivals that of the phosphoproteome. The remarkably ubiquitous and conserved nature of protein acetylation revealed by these new studies suggests the regulatory power of this dynamic modification. The establishment of comprehensive acetylomes will change the landscape of protein acetylation, where an exciting research frontier awaits.
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影响因子：
56.9
作者：
Choudhary, Chunaram;Kumar, Chanchal;Mann, Matthias
通讯作者：
Mann, Matthias
影响因子：
64.8
作者：
Hubbert, C;Guardiola, A;Yao, TP
通讯作者：
Yao, TP
DOI：
10.1083/jcb.200205057
发表时间：
2002-08-19
期刊：
The Journal of cell biology
影响因子：
--
作者：
Schwer B;North BJ;Frye RA;Ott M;Verdin E
通讯作者：
Verdin E
影响因子：
4.8
作者：
Bali, P;Pranpat, M;Bhalla, K
通讯作者：
Bhalla, K
影响因子：
16
作者：
Kovacs, JJ;Murphy, PJM;Yao, TP
通讯作者：
Yao, TP