The effects of exercise modalities on adiposity in obese rats
The effects of exercise modalities on adiposity in obese rats
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DOI：
10.6061/clinics/2012(12)19
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发表时间：
2012-12-01
期刊：
影响因子：
2.7
通讯作者：
Duarte, Ana Claudia Garcia de Oliveira
中科院分区：
文献类型：
--
作者：
Speretta, Guilherme Fleury Fina;Rosante, Marisa Cristina;Duarte, Ana Claudia Garcia de Oliveira
目的：观察游泳训练和抗阻训练对高脂饮食大鼠肿瘤坏死因子-α和白介素10表达、脂肪细胞面积和血脂的影响。方法：将Wistar成年大鼠分为安静饮食组、安静高脂饮食组、游泳+高脂饮食组、游泳+高脂饮食组、抗阻训练+高脂饮食组、阻力训练+高脂饮食组，每组10只。阻力训练组的大鼠每三天爬一次尾巴上有重量的垂直梯子。结果：高脂饮食组大鼠体重增加，脂肪组织增多，内脏脂肪组织中肿瘤坏死因子-α表达增加。此外，高脂饮食促进了血脂谱的负面变化。耐力训练高脂组肿瘤坏死因子-α表达低于游泳高脂组和久坐高脂组。此外，耐力训练高脂组的内脏和腹膜后脂肪细胞面积均小于久坐高脂组。游泳高脂组与静坐高脂组相比，肿瘤坏死因子-α表达降低，附睾区和腹膜后脂肪细胞面积缩小。结论：两种运动方式均能改善大鼠的脂代谢、肥胖和肥胖相关炎症反应，可作为控制高脂饮食有害影响的一种替代运动方式。
OBJECTIVE: The aim of the present study was to evaluate the effect of both swimming and resistance training on tumor necrosis factor-alpha and interleukin-10 expression, adipocyte area and lipid profiles in rats fed a high-fat diet.METHODS: The study was conducted over an eight-week period on Wistar adult rats, who were divided into six groups as follows (n = 10 per group): sedentary chow diet, sedentary high-fat diet, swimming plus chow diet, swimming plus high-fat diet, resistance training plus chow diet, and resistance training plus high-fat diet. Rats in the resistance training groups climbed a vertical ladder with weights on their tails once every three days. The swimming groups swam for 60 minutes/day, five days/week.RESULTS: The high-fat diet groups had higher body weights, a greater amount of adipose tissue, and higher tumor necrosis factor-alpha expression in the visceral adipose tissue. Furthermore, the high-fat diet promoted a negative change in the lipid profile. In the resistance training high-fat group, the tumor necrosis factor-alpha expression was lower than that in the swimming high-fat and sedentary high-fat groups. Moreover, smaller visceral and retroperitoneal adipocyte areas were found in the resistance training high-fat group than in the sedentary high-fat group. In the swimming high-fat group, the tumor necrosis factor-alpha expression was lower and the epididymal and retroperitoneal adipocyte areas were smaller compared with the sedentary high-fat group.CONCLUSION: The results showed that both exercise modalities improved the lipid profile, adiposity and obesity-associated inflammation in rats, suggesting their use as an alternative to control the deleterious effects of a high-fat diet in humans.