A simple solid-phase synthesis of the ubiquitous bacterial signaling molecule, c-di-GMP and analogues
A simple solid-phase synthesis of the ubiquitous bacterial signaling molecule, c-di-GMP and analogues
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DOI:
10.1039/b719423d
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发表时间:
2008-01-01
影响因子:
--
通讯作者:
Sintim, Herman O.
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文献类型:
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作者:
Kiburu, Irene;Shurer, Andrew;Sintim, Herman O.
Cyclic-di-guanylate (c-di-GMP) has emerged as a general and important signaling molecule uniquely present in bacteria: herein we provide a simple solid-phase synthesis of c-di-GMP using an automated DNA synthesizer for the majority of the synthesis.