CHRONIC VARIABLE STRESS FACILITATES TUMORAL GROWTH - REVERSAL BY IMIPRAMINE ADMINISTRATION
CHRONIC VARIABLE STRESS FACILITATES TUMORAL GROWTH - REVERSAL BY IMIPRAMINE ADMINISTRATION
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DOI：
10.1016/0024-3205(92)90063-u
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发表时间：
1992-01-01
期刊：
影响因子：
6.1
通讯作者：
MOLINA, VA
中科院分区：
文献类型：
--
作者：
BASSO, AM;DEPIANTEDEPAOLI, M;MOLINA, VA
本研究旨在研究慢性可变应激过程(CVS) -一种抑郁症动物模型-是否促进肿瘤生长，以及这种作用是否可以通过同时服用抗抑郁药丙咪嗪（IMI）来改变。无应激大鼠，既往给予或未给予免疫抑制剂环孢素（CS），接种5 × 10(6)个肉瘤细胞。另一组大鼠接种肿瘤细胞，随后暴露于CVS程序，同时或不同时给予IMI （10 mg/kg, i.p.）。另一组动物给予CS治疗，随后在无应激操作的情况下每天注射IMI （10 mg/kg, i.p）。在没有事先注射CS的未应激动物中观察到缺乏肿瘤发展，然而，事先注射这种免疫抑制剂会增加未应激动物的肿瘤生长。即使在没有注射CS的动物中，暴露于CVS程序也促进了肿瘤的生长。当慢性应激大鼠同时给予IMI时，这种效应明显减弱。这些发现支持了这样一种观点，即当实验性抑郁状态被诱导时，肿瘤过程的发展就会得到促进，而抗抑郁药物治疗可以逆转这种状态，从而抑制肿瘤的发展。
The present study was conducted to examine whether a chronic variable stress procedure (CVS) - an animal model of depression- facilitates tumor growth, and whether this effect can be modified by concurrent administration of the antidepressant imipramine (IMI). Unstressed rats, with or without previous administration of the immunosuppressive agent cyclosporine (CS), were inoculated with 5 x 10(6) cells of a sarcoma. Another group of rats was inoculated with tumoral cells and later exposed to the CVS procedure with or without concurrent administration of IMI (10 mg/kg, i.p.). An additional group of animals was treated with CS and later given daily injections of IMI (10 mg/kg, i.p.) without stress manipulation. A lack of tumoral development was observed in unstressed animals without previous injections of CS, whereas, prior injections of this immunosuppressive agent increased tumoral growth in unstressed animals. Exposure to the CVS procedure facilitated tumoral growth even in animals without CS injections. This effect was clearly attenuated when chronically stressed rats were concurrently given IMI. These findings support the notion that the development of a tumoral process is facilitated when a state of experimental depression is induced and that the reversal of such a state by antidepressant treatment results in the inhibition of tumor development.