Whey peptides improve wound healing following caesarean section in rats
Whey peptides improve wound healing following caesarean section in rats
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DOI：
10.1017/s0007114510002692
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发表时间：
2010-12-01
影响因子：
3.6
通讯作者：
Li, Yong
中科院分区：
文献类型：
--
作者：
Wang, Junbo;Zhao, Ming;Li, Yong
我们试图确定使用乳清肽（WP）剖腹产后治疗是否会影响产褥期大鼠皮肤和子宫切口的愈合。48只大鼠随机分为两组。剖宫产后，24只大鼠灌胃WP，其余大鼠灌胃对照组。于分娩后第7、14、21天，测定各组8只大鼠血清总蛋白/白蛋白浓度、皮肤抗张强度、子宫破裂压、皮肤/子宫羟脯氨酸（Hyp）浓度及瘢痕组织特征。WP组大鼠皮肤白蛋白浓度、皮肤抗张强度、子宫破裂压和Hyp浓度分别在第21、7、14和21天显著升高。第7天，WP组皮肤切口中性粒细胞计数较低，瘢痕宽度较小。剖宫产后应用白蜡可显著促进皮肤切口创面愈合，并具有显著的子宫创面愈合潜力。
We sought to determine whether postcaesarean treatment with whey peptides (WP) affects the healing of skin and uterine incision in rats during puerperium. Forty-eight rats were randomly divided into two groups. After a caesarean section, twenty-four rats were intragastrically administered WP, while others were administered a control vehicle. On days 7, 14 and 21 after delivery, the serum total protein/albumin concentration, skin tensile strength, uterine bursting pressure, skin/uterine hydroxyproline (Hyp) concentration and histological characteristics of the scar were measured in eight rats in each group. In the WP group, the albumin concentration, skin tensile strength, uterine bursting pressure and Hyp concentration in the skin increased significantly on days 21, 7, 14 and 21, respectively. Low neutrophil count and smaller scar width in the skin incision were found in the WP group on day 7. Postcaesarean treatment with WP promoted significant wound healing in the skin incision, and had a significant wound healing potential in the uterus.