Treatment with citalopram, but not with agomelatine, adversely affects sperm parameters: a case report and translational review
Treatment with citalopram, but not with agomelatine, adversely affects sperm parameters: a case report and translational review
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DOI：
10.1017/neu.2013.60
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发表时间：
2014-04-01
影响因子：
3.8
通讯作者：
Baldwin, David S.
中科院分区：
文献类型：
--
作者：
Elnazer, Hesham Y.;Baldwin, David S.
BackgroundAdverse effects of antidepressant drug treatmenton sexual function are well documented but the effects of antidepressants on sperm production have not been studied extensively.MethodsA narrative of an interventional case report of sperm parameters in a 30-year-old Caucasian man with a diagnosis of mixed depression and anxiety disorder，who undergoes citalopram treatment，followed by agomelatine treatment.临床观察结果促使对有关抗抑郁药给药或治疗对精子生成和参数影响的临床前和临床文献进行了综述。从审查结果进行了讨论，建议潜在的潜在mechanism.ResultsAbnormal精子参数与SSRI西酞普兰治疗。撤回后，精子浓度、活动力、前向活动力和精子形态均有改善。在随后的阿戈美拉汀治疗期间没有类似的相关性。临床观察反映了动物研究的结果，这表明，抗抑郁药可以对精子发生有不良影响。结论SSRI治疗可以与受损的精液质量。潜在的潜在机制包括精子DNA完整性的变化、IDO的激活和色氨酸代谢的改变。进一步研究抗抑郁药对精子发生的影响，可能会受益于包括在抗抑郁药给药期间IDO活性的变化调查。
BackgroundAdverse effects of antidepressant drug treatmenton sexual function are well documented but the effects of antidepressants on sperm production have not been researched extensively.MethodsA narrative of an interventional case report of sperm parameters in a 30-year-old Caucasian man with a diagnosis of mixed depressive and anxiety disorder, who underwent citalopram treatment, followed by agomelatine treatment. Clinical observations prompted a review of the pre-clinical and clinical literature on the effects of antidepressant administration or treatment on sperm production and parameters. Findings from the review are discussed to suggest potential underlying mechanisms.ResultsAbnormal sperm parameters were associated with treatment with the SSRI citalopram. There was an improvement in sperm concentration, motility, progressive motility and sperm morphology following its withdrawal. There was no similar association during subsequent treatment with agomelatine. The clinical observations reflect findings from animal studies, which indicate that antidepressants can have untoward effects on spermatogenesis.ConclusionsSSRI treatment can be associated with impaired semen quality. Potential underlying mechanisms include changes in sperm DNA integrity, activation of IDO and shifting tryptophan metabolism. Further studies of the effects of antidepressants on spermatogenesis might benefit from including investigation of changes in IDO activity during antidepressant administration.