The role of ubiquitination in the direct mitochondrial death program of p53
The role of ubiquitination in the direct mitochondrial death program of p53
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DOI：
10.4161/cc.6.14.4503
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发表时间：
2007-07-15
期刊：
影响因子：
4.3
通讯作者：
Moll, Ute M.
中科院分区：
文献类型：
--
作者：
Marchenko, Natasha D.;Moll, Ute M.
通过MDM 2和其他E3连接酶在C-末端赖氨酸处的p53泛素化被认为是p53的直接负调节，其仅具有一个功能，即标记蛋白质用于蛋白酶体降解。在这篇综述中，我们将集中在最近发现的激活作用的泛素化的转录独立的直接线粒体死亡程序的p53。
p53 ubiquitination at C-terminal lysines by MDM2 and other E3 ligases had been considered a straightforward negative regulation of p53 with only one function, that is marking the protein for proteasomal degradation. In this review, we will focus on the recently uncovered activating role of ubiquitination in the transcription-independent direct mitochondrial death program of p53.