Prevention of hereditary carcinogenesis
Prevention of hereditary carcinogenesis
复制标题
预防遗传性致癌
DOI：
10.2183/pjab.78.30
复制
发表时间：
2002
期刊：
影响因子：
11.2
通讯作者：
H. Mitani
中科院分区：
文献类型：
--
作者：
O. Hino;Toshiyuki Kobayashi;H. Mitani
癌症是一种体细胞遗传性疾病。环境和遗传共同作用于人类癌症的起源。动物遗传性癌症为了解疾病机制、开发可应用于人类患者的治疗方法以及环境因素如何与癌症易感基因相互作用提供了有价值的实验模型。在这里，我们展示了通过引入 IFN-y 转基因来预防 Tsc2 基因突变型遗传性肾癌发生的癌症的例子。
Cancer is a heritable disorder of somatic cells. The environment and heredity both operate in the origin of human cancer. Hereditary cancers in animals provide valuable experimental models for understanding the mechanisms of disease, and the development of the therapeutic treatments which can be translated into human patients, as well as how environmental factors interact with cancer susceptibility genes. Here, we show the example for cancer prevention in Tsc2 gene mutant hereditary renal carcinogenesis by introducing IFN-y transgene.