Selective Changes in Noise Correlations Contribute to an Enhanced Representation of Saccadic Targets in Prefrontal Neuronal Ensembles.
Selective Changes in Noise Correlations Contribute to an Enhanced Representation of Saccadic Targets in Prefrontal Neuronal Ensembles.
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DOI：
10.1093/cercor/bhy141
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发表时间：
2018-08-01
期刊：
影响因子：
--
通讯作者：
Soltani A
中科院分区：
文献类型：
--
作者：
Dehaqani MA;Vahabie AH;Parsa M;Noudoost B;Soltani A
神经元的集合可以提供外部刺激、正在进行的过程或即将发生的动作的动态表示。这种动态表征可以通过改变单个神经元的活动和/或它们之间的相互作用来实现。为了研究这些可能性，我们同时记录了非人类灵长类动物在记忆引导的扫视任务中前额叶神经元的集合。采用解码和编码两种方法，我们研究了单个神经元和集合的信息含量在视觉编码和跳跃性目标选择之间的变化。我们发现单个神经元在这些认知状态之间保持有限的空间敏感性，而集合选择性地改进了远离神经元首选位置的空间位置的编码。这种种群水平的“编码扩展”不是由于首选位置的天花板效应，而是伴随着非首选位置的噪声相关性的选择性变化。此外，在不同类型的神经元集合中观察到编码扩展，并且不能用单个神经元首选位置的变化来解释。我们的研究结果表明，在扫视之前，神经元集合对空间的表征是动态增强的，这种增强是伴随着噪声相关性的变化而不是单个神经元活动的变化而发生的。
An ensemble of neurons can provide a dynamic representation of external stimuli, ongoing processes, or upcoming actions. This dynamic representation could be achieved by changes in the activity of individual neurons and/or their interactions. To investigate these possibilities, we simultaneously recorded from ensembles of prefrontal neurons in non-human primates during a memory-guided saccade task. Using both decoding and encoding methods, we examined changes in the information content of individual neurons and that of ensembles between visual encoding and saccadic target selection. We found that individual neurons maintained their limited spatial sensitivity between these cognitive states, whereas the ensemble selectively improved its encoding of spatial locations far from the neurons’ preferred locations. This population-level “encoding expansion” was not due to the ceiling effect at the preferred locations and was accompanied by selective changes in noise correlations for non-preferred locations. Moreover, the encoding expansion was observed for ensembles of different types of neurons and could not be explained by shifts in the preferred location of individual neurons. Our results demonstrate that the representation of space by neuronal ensembles is dynamically enhanced prior to saccades, and this enhancement occurs alongside changes in noise correlations more than changes in the activity of individual neurons.
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DOI：
10.1073/pnas.1619949114
发表时间：
2017-03-21
影响因子：
11.1
作者：
Leavitt, Matthew L.;Pieper, Florian;Martinez-Trujillo, Julio C.
通讯作者：
Martinez-Trujillo, Julio C.
影响因子：
64.8
作者：
Gutnisky, Diego A.;Dragoi, Valentin
通讯作者：
Dragoi, Valentin
影响因子：
3
作者：
Mazzucato L;Fontanini A;La Camera G
通讯作者：
La Camera G
影响因子：
4.3
作者：
Adibi M;McDonald JS;Clifford CW;Arabzadeh E
通讯作者：
Arabzadeh E
影响因子：
3
作者：
Barnett, Alex H.;Magland, Jeremy F.;Greengard, Leslie F.
通讯作者：
Greengard, Leslie F.