Displacement Imaging During Focused Ultrasound Median Nerve Modulation: A Preliminary Study in Human Pain Sensation Mitigation.
Displacement Imaging During Focused Ultrasound Median Nerve Modulation: A Preliminary Study in Human Pain Sensation Mitigation.
复制标题
聚焦超声中间神经调节过程中的位移成像：在缓解人类疼痛的初步研究。
DOI：
10.1109/tuffc.2020.3014183
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Konofagou EE
中科院分区：
文献类型：
--
作者：
Lee SA;Kamimura HAS;Konofagou EE
Focused Ultrasound (FUS)-based viscoelastic imaging techniques using high-frame-rate (HFR) ultrasound to track tissue displacement can be used for mechanistic monitoring of FUS neuromodulation. However, a majority of techniques avoid imaging during the active push transmit (interleaved or post-push acquisitions) to mitigate ultrasound interference, which leads to missing temporal information of ultrasound effects when FUS is being applied. Furthermore, critical for clinical translation, use of both axial steering and real-time (<1s) capabilities for optimizing acoustic parameters for tissue engagement are largely missing. In this study, we describe a method of non-interleaved, single Vantage imaging displacement within an active FUS push with simultaneous axial steering and real-time capabilities using a single ultrasound acquisition machine. Results show that the pulse sequence can track micron-sized displacements using frame rates determined by the calculated time-of-flight (TOF), without interleaving the FUS pulses and imaging acquisition. Decimation by 3–7 frames increases SNR by 15.09±7.03 dB. Benchmarking tests of CUDA-optimized code show increases in processing speed of 35 -and 300-fold in comparison with MATLAB parallel processing GPU and CPU functions, respectively and we can estimate displacement from steered push beams ±10 mm from the geometric focus. Preliminary validation of displacement imaging in humans show that the same driving pressures led to variable nerve engagement, demonstrating important feedback to improve transducer coupling, FUS incident angle, and targeting. Regarding the use of our technique for neuromodulation, we found that FUS altered thermal perception of thermal pain by 0.9643 units of pain ratings in a single trial. Additionally, 5 microns of nerve displacement was shown in on-target vs. off-target sonications. The initial feasibility in healthy volunteers warrants further study for potential clinical translation of FUS for pain suppression.
