Adherence to BCR-ABL inhibitors: issues for CML therapy.
Adherence to BCR-ABL inhibitors: issues for CML therapy.
复制标题
遵守BCR-ABL抑制剂：CML治疗问题。
DOI：
10.1016/j.clml.2012.04.002
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发表时间：
2012-08
期刊：
影响因子：
--
通讯作者：
Kantarjian H
中科院分区：
文献类型：
--
作者：
Jabbour E;Saglio G;Radich J;Kantarjian H
慢性粒细胞白血病（CML）的治疗在过去的20年里有了很大的改善，特别是自从十年前引入口服BCR-ABL抑制剂以来。然而，对于患者来说，要获得BCR-ABL抑制剂的益处，他们可能必须在余生中接受治疗。在这种情况下，坚持服药成为一个问题。已证明慢性健康状况（包括CML）的治疗依从性较差。研究表明，CML患者中三分之一或更多患者的不依从性很常见，100%依从性很罕见。此外，有证据表明，对BCR-ABL抑制剂的依从性降低与疗效降低和医疗费用增加有关。可能导致不依从的因素，包括剂量，毒性，从诊断到处方的时间，以及合并用药的数量，应由医生处理和监测。为了最大限度地提高依从性，CML治疗应根据患者个体化并酌情简化。
Treatment for chronic myeloid leukemia (CML) has improved substantially in the last 20 years, especially since the introduction of oral BCR-ABL inhibitors a decade ago. However, for patients to reap the benefits of BCR-ABL inhibitors, they must likely be on therapy for the remainder of their lives. In this situation, adherence to medication becomes a concern. Adherence to therapy for chronic health conditions, including CML, has been demonstrated to be poor. Studies have shown nonadherence in CML to be common in one-third or more of patients, and 100% adherence is rare. Furthermore, evidence suggests that reduced adherence to BCR-ABL inhibitors is associated with reduced efficacy and increased healthcare costs. Factors that can cause nonadherence, including dose, toxicity, time from diagnosis to prescription, and the number of concomitant medications, should be addressed and monitored by the physician. To maximize adherence, CML treatment should be individualized to the patient and simplified as appropriate.
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