Inflammatory cytokines correlated with clinical outcome of temporomandibular joint irrigation in patients with chronic closed lock
Inflammatory cytokines correlated with clinical outcome of temporomandibular joint irrigation in patients with chronic closed lock
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DOI：
10.1016/j.tripleo.2005.11.010
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发表时间：
2006-11-01
期刊：
影响因子：
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通讯作者：
Matsudo, Yokohama
中科院分区：
文献类型：
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作者：
Hamada, Yoshiki;Kondoh, Toshirou;Matsudo, Yokohama
目标。本研究旨在探讨慢性闭锁(CCL)患者关节冲洗液中肿瘤坏死因子(TNF)-α、白介素1-β(IL-1β)、白介素6(IL-6)、白介素8(IL-8)、白介素12(IL-12)和白介素10(IL-10)的含量与TMJ冲洗治疗效果的相关性。36例患者接受了目视引导下TMJ冲洗(VGIR)。在VGIR前立即采集SF样本。将患者分为成功组(S组，n=25)和不成功组(u组，n=11)。测量SF中每毫克总蛋白中每毫克细胞因子的检测率和浓度，并比较S组和u组之间的差异。所有被调查的细胞因子都能以不同的速率、浓度和结合模式被检测到。U组IL-6的检测率和浓度明显高于U组，而S组IL-10的检测率和浓度明显高于U组。这些细胞因子可能参与了TMJ CCL的病理生理过程。结果还表明，SF中的IL-6是一个不成功结局的指标，而IL-10是TMJ冲洗治疗CCL成功结局的重要预测因子。
Objective. This study investigated the correlation of clinical outcomes of temporomandibular joint (TMJ) irrigation with the occurrence and concentrations of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1 beta, IL-6, IL-8, IL-12, and IL-10 in the washed-out synovial fluid (SF) in patients with chronic closed lock (CCL) of the TMJ.Study design. Thirty-six patients underwent a visually guided TMJ irrigation (VGIR). SF samples were collected immediately before VGIR. The patients were divided into either successful (s-group; n = 25) or unsuccessful groups (u-group; n = 11). The detection rates and concentrations of each cytokine per milligram of total protein in the SF were measured, and then compared between the s- and u-groups.Results. All of the investigated cytokines were detectable with various rates, concentrations, and combination patterns. The detection rate and concentrations of IL-6 were significantly higher in the u-group, and those of IL-10 were significantly higher in the s-group.Conclusions. The investigated cytokines were suggested to be involved in the pathophysiology of TMJ CCL. The results also suggest that IL-6 in the SF is an indicator of an unsuccessful outcome, and that IL-10 is a significant predictor of a successful outcome of TMJ irrigation for CCL.