Prevalence of movement disorders in men and women aged 50-89 years (Bruneck Study cohort):: a population-based study
Prevalence of movement disorders in men and women aged 50-89 years (Bruneck Study cohort):: a population-based study
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DOI：
10.1016/s1474-4422(05)70226-x
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发表时间：
2005-12-01
期刊：
影响因子：
48
通讯作者：
Poewe, W
中科院分区：
文献类型：
--
作者：
Wenning, GK;Kiechl, S;Poewe, W
背景：人们逐渐意识到运动障碍是最常见的神经系统疾病之一。然而，这些疾病在一般社区的总体负担并未得到很好的界定。我们试图评估所有常见类别的运动障碍在人群中的患病率，考虑到性别差异和年龄趋势。方法作为正在进行的基于人群的颈动脉粥样硬化和中风风险前瞻性研究(Bruneck研究)的一部分，总共706名年龄在50-之间的男性和女性接受了彻底的神经学评估。运动障碍的诊断和疾病严重程度的评级基于标准标准和量表。根据Logistic回归模型(回归平滑率)估计患病率，并对一般社区的年龄和性别结构进行标准化。发现所有常见类别的运动障碍的患病率为28.0%(95%可信区间为25.9-30-1)。男性(27.6%[95%可信区间24.5-30-7])和女性(28.3%[25.5-31-2])比例相近，且随着年龄的增长而急剧增加(从50-59岁的18.5%[15.0-22.0]上升到80-89岁的51.3%[44.9-57-7])。几乎一半的患者(90/214)有中到重度疾病的表达，但只有7.0%(15/214)的患者接受了标准药物治疗。震颤的发生率为14.5%，其次是不宁腿综合征(10.8%)，帕金森综合征(7%)，原发性和继发性肌张力障碍(1.8%)，舞蹈和痉挛(
Background There is emerging awareness that movement disorders rank among the most common neurological diseases. However, the overall burden of these disorders in the general community is not well defined. We sought to assess the prevalence of all common categories of movement disorders in a population, accounting for sex differences and age trends.Methods As part of an ongoing prospective population-based study of carotid atherosclerosis and stroke risk (the Bruneck Study), a total of 706 men and women aged 50-89 years underwent a thorough neurological assessment. The diagnosis of movement disorders and ratings for disease severity were based on standard criteria and scales. Prevalences were estimated from logistic regression models (regression-smoothed rates) and standardised to the age and sex structure of the general community.Findings The prevalence of all common categories of movement disorders was 28.0% (95% CI 25.9-30-1). Proportions in men (27.6% [95% CI 24.5-30-7]) and women (28.3% [25.5-31-2]) were closely similar and sharply increased with age (from 18.5% [15.0-22.0] in 50-59-year olds to 51.3% [44.9-57-7] in 80-89-year olds). Almost half of all patients (90/214) had moderate-to-severe disease expression, but only 7.0% (15/214) received standard drug treatment. Prevalence of tremor was 14.5%, followed by restless legs syndrome (10-8%), parkinsonism (7%), primary dystonia and secondary dystonia (1.8%), and chorea and tics (