Models of protein sequence evolution and their applications
Models of protein sequence evolution and their applications
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DOI：
10.1016/s0959-437x(00)00142-8
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发表时间：
2000-12-01
影响因子：
4
通讯作者：
Thorne, JL
中科院分区：
文献类型：
--
作者：
Thorne, JL
同源序列由于它们的共同祖先而相关。序列进化的概率模型通常用于正确解释这些系统发育相关性。这些越来越现实的模型为研究进化和利用它更好地理解蛋白质结构和功能提供了基础。最近在插入和缺失事件的处理、氨基酸置换率的估计和阳性选择的检测方面取得了显著的进展。
Homologous sequences are correlated due to their common ancestry. Probabilistic models of sequence evolution are employed routinely to properly account for these phylogenetic correlations. These increasingly realistic models provide a basis for studying evolution and for exploiting it to better understand protein structure and function. Notable recent advances have been made in the treatment of insertion and deletion events, the estimation of amino-acid replacement rates, and the detection of positive selection.