Superantigens and endogenous retroviruses: a confluence of puzzles.
Superantigens and endogenous retroviruses: a confluence of puzzles.
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超级抗原和内源性逆转录病毒：谜题的汇合。
DOI：
10.1126/science.1310360
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Coffin,JM
中科院分区：
文献类型：
--
作者：
Coffin,JM
24 JANUARY 1992 compatibility complex (MHC) class II molecules, specifically bind to certain subsets of T cell receptor (TCR) P chains (4). This binding causes stimulation of T helper cell function as though the cell had been exposed to antigen in the context of a presenting cell. Endogenous superantigens were first identified as genetic ele-ments that could stimulate T cell proliferation in mixed cultures of lymphocytes from mice that were matched at the MHC. The genes responsible forthis effect were named Mis (for minor lymphocyte stimulating), and several distinctloci have been identified. Like bacterial superantigens, Mls stimulates only T cells that express a particular one (or a subset) of the 20 or so genes encoding alternative 1P chains of the TCR (Table 1). But like normal antigens, stimulation requires presentation of the Mbs product together with MHC classII proteins on the surface of antigen-presenting cells. During development, mice that have Mis actively delete those T cells that express the V. subset or subsets that recognize the specific Mls product. The genetics ofMbs were initially confusing, but eventually it was recognized thatthere are several distinct Mis loci, each of which has two alleles: a positive allele that confers a specific pattern of V. reactivity and a negative or null allele that confers no reactivity. Although the properties ofMls proteins had been inferred
