The Role of Hepcidin in Iron Metabolism
The Role of Hepcidin in Iron Metabolism
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DOI：
10.1159/000243791
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发表时间：
2009-01-01
影响因子：
2.4
通讯作者：
Ganz, Tomas
中科院分区：
文献类型：
--
作者：
Nemeth, Elizabeta;Ganz, Tomas
铁调素是系统性铁稳态的中心调节剂。铁调素产生的失调导致各种铁紊乱。铁调素缺乏是遗传性血色素沉着症、铁负荷性贫血和丙型肝炎中铁超载的原因。铁调素过量与炎症性贫血、慢性肾病和铁难治性缺铁性贫血有关。这一新知识的诊断和治疗应用正开始出现。Ernest Beutler博士在促进我们对hepcidin功能的理解方面发挥了重要作用。这篇评论是为了纪念他。版权所有（C）2009 S. Karger AG，巴塞尔
Hepcidin is the central regulator of systemic iron homeostasis. Dysregulation of hepcidin production results in a variety of iron disorders. Hepcidin deficiency is the cause of iron overload in hereditary hemochromatosis, iron-loading anemias, and hepatitis C. Hepcidin excess is associated with anemia of inflammation, chronic kidney disease and iron-refractory iron deficiency anemia. Diagnostic and therapeutic applications of this new knowledge are beginning to emerge. Dr. Ernest Beutler played a significant role in advancing our understanding of the function of hepcidin. This review is dedicated to his memory. Copyright (C) 2009 S. Karger AG, Basel