A surface-based analysis of hemispheric asymmetries and folding of cerebral cortex in term-born human infants.
A surface-based analysis of hemispheric asymmetries and folding of cerebral cortex in term-born human infants.
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DOI：
10.1523/jneurosci.4682-09.2010
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发表时间：
2010-02-10
期刊：
影响因子：
--
通讯作者：
Van Essen D
中科院分区：
文献类型：
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作者：
Hill J;Dierker D;Neil J;Inder T;Knutsen A;Harwell J;Coalson T;Van Essen D
我们建立了足月妊娠时人类大脑皮层的人口平均表面图谱，并用它来比较婴儿和成人皮质形状特征。使用新颖的分割算法，根据结构磁共振成像数据生成 12 名健康足月妊娠婴儿每个半球的准确皮质表面重建。每个表面都经过膨胀、展平、映射到标准球形配置，并配准到目标图谱球体，该球体使用地标约束表面配准反映了所有 24 个贡献半球的形状特征。生成脑沟深度、深度变异性、3维位置变异性和半球深度不对称性的群体平均图，并与先前建立的成人皮质图进行比较。我们发现足月婴儿的皮质结构在许多方面与成人相似，包括个体差异模式以及外侧颞叶皮层（包括颞平面和颞上沟）存在统计学上显着的结构不对称性。这些结果表明，皮质形状的几个特征受产后环境的影响最小。
We have established a population average surface based atlas of human cerebral cortex at term gestation and used it to compare infant and adult cortical shape characteristics. Accurate cortical surface reconstructions for each hemisphere of 12 healthy term gestation infants were generated from structural magnetic resonance imaging data using a novel segmentation algorithm. Each surface was inflated, flattened, mapped to a standard spherical configuration, and registered to a target atlas sphere that reflected shape characteristics of all 24 contributing hemispheres using landmark constrained surface registration. Population average maps of sulcal depth, depth variability, 3-dimensional positional variability, and hemispheric depth asymmetry were generated and compared to previously established maps of adult cortex. We found that cortical structure in term infants is similar to the adult in many respects, including the pattern of individual variability and the presence of statistically significant structural asymmetries in lateral temporal cortex, including the planum temporale and superior temporal sulcus. These results indicate that several features of cortical shape are minimally influenced by the postnatal environment.