DEFINITION OF CLINICALLY RELEVANT LACTIC-ACIDOSIS IN PATIENTS WITH INTERNAL DISEASES
DEFINITION OF CLINICALLY RELEVANT LACTIC-ACIDOSIS IN PATIENTS WITH INTERNAL DISEASES
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DOI：
10.1093/ajcp/80.4.484
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发表时间：
1983-01-01
影响因子：
3.5
通讯作者：
EGGSTEIN, M
中科院分区：
文献类型：
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作者：
LUFT, D;DEICHSEL, G;EGGSTEIN, M
为了明确乳酸酸中毒的临床相关性，对连续入院的约2000例内科疾病患者进行了12项生化指标、8项临床症状和体征、主要诊断和死亡率的前瞻性评估。数据集不完整的患者不被考虑。在研究期间反复入院的患者中，只有第一次入院的患者被纳入统计分析。除了文献中给出的11个乳酸酸中毒的定义外，对生化变量的序贯聚类分析被用来估计1467名患者的乳酸酸中毒的发生率。根据使用的定义，0.5-3.8%的患者被归类为乳酸中毒，死亡率从30%-88%不等。限制为.ltoreq。7.35的pH和5-6 mm的全血乳酸浓度将最大限度地减少假阴性或假阳性分类。
To define clinically relevant lactic acidosis, 12 biochemical variables, 8 clinical symptoms and signs, leading diagnoses and mortality were evaluated prospectively in approximately 2000 unselected patients with internal diseases, consecutively admitted to the hospital. Patients with incomplete data sets were not considered. Of those patients who repeatedly were admitted to the hospital during the time of the study, only the 1st admission was included for statistical analysis. In addition to 11 definitions of lactic acidosis given in the literature, sequential cluster analyses of the biochemical variables were used to estimate the incidence of lactic acidosis in 1467 patients. Depending upon which definition was used, 0.5-3.8% of all patients were classified as suffering from lactic acidosis, with a mortality rate ranging from 30-88%. A limit of .ltoreq. 7.35 for pH and of > 5-6 mM for the concentration of lactate in whole blood will minimize false-negative or false-positive classifications.