MD-2
MD-2
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DOI：
10.1016/j.imbio.2006.05.010
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发表时间：
2006-01-01
期刊：
影响因子：
2.8
通讯作者：
Golenbock, Douglas T.
中科院分区：
文献类型：
--
作者：
Visintin, Alberto;Iliev, Dimitar B.;Golenbock, Douglas T.
Toll样受体(Toll-like Receptor，TLRs)是一类I型糖蛋白的小家族，与微生物携带的保守的非自身分子信号结合并被激活。Toll样受体4是由大多数脂多糖(LPS)触发的。脂多糖是一种来源于革兰氏阴性菌的两亲性糖脂多糖。在TLR中，TLR4的活性和与其天然配体(S)的相互作用严格依赖于细胞外适配器MD-2的存在。MD-2是一种小的分泌型糖蛋白，它与脂多糖的疏水部分和TLR4的胞外结构域结合有细胞因子样的亲和力。MD-2与内毒素的相互作用诱导TLR4上的一个触发事件，该事件涉及受体复合体的分子重排及其同型聚集。计算机分析表明，MD-2和MD-1是从早期脊椎动物水平上的共同前身衍生而来的同源基因。在这篇综述中，我们总结了关于MD-2的知识现状。(C)2006年爱思唯尔股份有限公司。版权所有。
Toll-like receptors (TLRs) are a small family of type-I glycoproteins that bind to and are activated by conserved non-self molecular signatures carried by microorganisms. Toll-like receptor 4 is triggered by most lipopolysaccharides (LPS). LPS is a complex amphipathic saccharolipidic glycan derived from Gram-negative bacteria. Unique among TLRs, TLR4 activity and interaction with its natural ligand(s) strictly depends on the presence of the extracellular adaptor MD-2. MD-2 is a small secreted glycoprotein that binds with cytokine-like affinities to both the hydrophobic portion of LPS and to the extracellular domain of TLR4. The interaction between MD-2 and LPS induces a triggering event on TLR4, which involves the molecular rearrangement of the receptor complex and its homotypic aggregation. In silico analysis suggests that MD-2 and MD-1 are paralogs derived from a common predecessor at the level of early vertebrates. In this review, we summarize the current state of knowledge concerning MD-2. (c) 2006 Elsevier GmbH. All rights reserved.