Synthesis of L- and D-[methyl-11C]methionine.
Synthesis of L- and D-[methyl-11C]methionine.
复制标题
L-和D-[甲基-11C]蛋氨酸的合成。
作者：
B. Långström;G. Antoni;P. Gullberg;C. Halldin;P. Malmborg;K. Någren;A. Rimland;H. Svärd
本报告描述了纯对映体形式的L-和D-[甲基-11 C]蛋氨酸的合成。这些化合物常规制备约1，000次，失败次数少于20次。以一锅法或两锅法制备的简单单碳前体碳-11（11 C）碘甲烷为原料，分别制备了光学纯度大于99%的L-和D-[甲基-11C]蛋氨酸，放化产率为40%~ 90%。从[11 C]二氧化碳开始合成的总时间为12-15分钟。粗产物通常具有大于95%的放射化学纯度。合成的总时间，包括LC纯化，为20-30分钟。在每种情况下，产物的放射化学纯度大于98%。
This report describes the synthesis of L- and D-[methyl-11C]methionine in pure enantiomeric forms. The compounds were prepared routinely approximately 1,000 times with less than 20 failures. Starting with carbon-11 (11C) methyl iodide, a simple one-carbon precursor produced from a one-pot or a two-pot apparatus, L- and D-[methyl-11C]methionine were prepared, respectively, with an optical purity higher than 99% in 40%-90% radiochemical yields. The total time for synthesis, starting from [11C]carbon dioxide, was 12-15 min. The crude product usually had a radiochemical purity greater than 95%. The total time for synthesis, including LC purification, was 20-30 min. The radiochemical purity of the product in each case was greater than 98%.