Advancing human circadian rhythms with afternoon melatonin and morning intermittent bright light
Advancing human circadian rhythms with afternoon melatonin and morning intermittent bright light
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DOI：
10.1210/jc.2005-1009
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发表时间：
2006-01-01
影响因子：
5.8
通讯作者：
Eastman, CI
中科院分区：
文献类型：
--
作者：
Revell, VL;Burgess, HJ;Eastman, CI
内容：光和褪黑激素都可以用来改变人体生物钟的相位，但是两者结合的相位提前效应还没有得到广泛的研究。目的：本研究的目的是确定是否可以用下午的褪黑激素来增加由早晨间歇性明亮的光和逐渐提前的睡眠时间表引起的相位提前。健康成人（25名男性，19名女性，年龄在19到45岁之间）参与了这项研究。设计：有3天的逐渐推进的睡眠/黑暗期（每天早上提前1小时唤醒），唤醒时的强光[四个30分钟的强光脉冲（类似于5000勒克斯）与30分钟的室内光交替
Context: Both light and melatonin can be used to phase shift the human circadian clock, but the phase-advancing effect of the combination has not been extensively investigated.Objective: The objective of the study was to determine whether phase advances induced by morning intermittent bright light and a gradually advancing sleep schedule could be increased with afternoon melatonin.Participants: Healthy adults (25 males, 19 females, between the ages of 19 and 45 yr) participated in the study.Design: There were 3 d of a gradually advancing sleep/dark period (wake time 1 h earlier each morning), bright light on awakening [ four 30-min bright-light pulses (similar to 5000 lux) alternating with 30 min room light