Adipose-Derived Stem Cells in Functional Bone Tissue Engineering: Lessons from Bone Mechanobiology
Adipose-Derived Stem Cells in Functional Bone Tissue Engineering: Lessons from Bone Mechanobiology
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DOI：
10.1089/ten.teb.2010.0738
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发表时间：
2011-06-01
影响因子：
6.4
通讯作者：
Loboa, Elizabeth G.
中科院分区：
文献类型：
--
作者：
Bodle, Josephine C.;Hanson, Ariel D.;Loboa, Elizabeth G.
本文从骨力学生物学的角度综述了脂肪源性干细胞（ASC）在功能性骨组织工程中的应用。一个多世纪以来对骨力学敏感性原理的研究现在正被应用于我们对骨发育的理解。我们刚刚开始利用干细胞在骨组织工程中的潜力。ASC是本综述的主要焦点，因为它们丰富且相对容易获得自体手术。本文概述了目前骨力学生物学的知识基础，以研究如何将该领域的知识应用于各种基于干细胞的工程骨组织构建方法。特别强调的是在此应用程序中使用人类ASC。
This review aims to highlight the current and significant work in the use of adipose-derived stem cells (ASC) in functional bone tissue engineering framed through the bone mechanobiology perspective. Over a century of work on the principles of bone mechanosensitivity is now being applied to our understanding of bone development. We are just beginning to harness that potential using stem cells in bone tissue engineering. ASC are the primary focus of this review due to their abundance and relative ease of accessibility for autologous procedures. This article outlines the current knowledge base in bone mechanobiology to investigate how the knowledge from this area has been applied to the various stem cell-based approaches to engineering bone tissue constructs. Specific emphasis is placed on the use of human ASC for this application.