CD109 expression in squamous cell carcinoma of the uterine cervix
CD109 expression in squamous cell carcinoma of the uterine cervix
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DOI：
10.1111/j.1440-1827.2005.01807.x
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发表时间：
2005-04-01
影响因子：
2.2
通讯作者：
Takahashi, M
中科院分区：
文献类型：
--
作者：
Zhang, JM;Hashimoto, M;Takahashi, M
CD 109是一种细胞表面蛋白，是α（2）巨球蛋白/含硫酯蛋白的C3、C4、C5家族的成员。作者最近报道，高表达的CD 109基因被检测到在大约一半的检查肺和食管鳞状细胞癌以及在睾丸，和CD 109具有癌症-睾丸抗原的特性。本研究采用逆转录聚合酶链反应（RT-PCR）方法，比较了CD 109在子宫颈鳞癌和子宫内膜腺癌中的表达。结果表明，CD 109在宫颈鳞癌中的表达明显高于子宫内膜腺癌和正常宫颈及子宫内膜。相反，当检测RET指蛋白（RFP）和溴结构域睾丸特异性（BRDT）基因（也已知在睾丸中高度表达）的表达时，在鳞状细胞癌和腺癌之间未观察到其表达水平的显著差异。这些研究结果表明，CD 109可能成为一个分子靶点，为各种组织来源的鳞状细胞癌的新疗法的发展。
CD109 is a cell surface protein, a member of the alpha(2) macroglobulin/C3,C4,C5 family of thioester-containing proteins. The authors have recently reported that high expression of the CD109 gene was detected in approximately half of the examined lung and esophageal squamous cell carcinomas as well as in the testis, and that CD109 has the characteristics of a cancer-testis antigen. In the present study CD109 expression in cervical squamous cell carcinoma was compared with that in endometrial adenocarcinoma by reverse transcription polymerase chain reaction (RT-PCR). The result demonstrated that CD109 expression is significantly higher in cervical squamous cell carcinomas than in endometrial adenocarcinomas and normal cervix and endometrium. In contrast, when expression of RET finger protein (RFP) and bromodomain testis-specific (BRDT) genes, which are also known to be highly expressed in the testis, was examined, no significant difference in their expression levels was observed between squamous cell carcinomas and adenocarcinomas. These findings suggest that CD109 may become a molecular target for the development of new therapeutics for squamous cell carcinoma of various tissue origins.