Correlation between three-dimensional ultrasound features and pathological prognostic factors in breast cancer
Correlation between three-dimensional ultrasound features and pathological prognostic factors in breast cancer
复制标题
乳腺癌三维超声特征与病理预后因素的相关性
DOI：
10.1007/s00330-014-3135-8
复制
发表时间：
2014-06-01
影响因子：
5.9
通讯作者：
Wang, Xiao-jin
中科院分区：
文献类型：
--
作者：
Jiang, Jun;Chen, Ya-qing;Wang, Xiao-jin
为探讨乳腺浸润性导管癌三维（3D）超声表现与预后因素的关系，收集85例乳腺浸润性导管癌手术切除标本，均行3D超声检查。评价三维超声的形态学特征和血管灌注情况。病理预后因素，包括肿瘤大小，组织学分级，淋巴结状态，雌激素和孕激素受体状态（ER，PR），c-erbB-2和p53的表达，和微血管密度（MVD）进行了测定。分析3D超声特征与预后因素的相关性，冠状面的收缩模式作为肿瘤小（P = 0.014）、组织学分级低（P = 0.009）和ER或PR阳性表达状态（P = 0.001，0.044）的独立预测因子具有显著价值。高回声环的回缩模式仅存在于低级别和ER阳性肿瘤中。高回声环的存在加强了收缩模式预测乳腺癌良好预后的能力。肿瘤内血管化指数增加（VI，平均肿瘤血管）反映了较高的组织学分级与MVD呈正相关（P = 0.025）（r = 0.530，P = 0.001）。三维超声提供的VI收缩模式和直方图指数可能有助于预测乳腺癌的预后信息。三维超声可以潜在地提供乳腺癌的预后评估。a Euro cent冠状面中的收缩模式和高回声环表明预后良好。a Euro cent肿瘤内血管化指数的增加反映了较高的组织学分级。a Euro cent肿瘤内血管化指数与微血管密度呈正相关。
To investigate the correlation of three-dimensional (3D) ultrasound features with prognostic factors in invasive ductal carcinoma.Surgical resection specimens of 85 invasive ductal carcinomas of 85 women who had undergone 3D ultrasound were included. Morphology features and vascularization perfusion on 3D ultrasound were evaluated. Pathologic prognostic factors, including tumour size, histological grade, lymph node status, oestrogen and progesterone receptor status (ER, PR), c-erbB-2 and p53 expression, and microvessel density (MVD) were determined. Correlations of 3D ultrasound features and prognostic factors were analysed.The retraction pattern in the coronal plane had a significant value as an independent predictor of a small tumour size (P = 0.014), a lower histological grade (P = 0.009) and positive ER or PR expression status (P = 0.001, 0.044). The retraction pattern with a hyperechoic ring only existed in low-grade and ER-positive tumours. The presence of the hyperechoic ring strengthened the ability of the retraction pattern to predict a good prognosis of breast cancer. The increased intra-tumour vascularization index (VI, the mean tumour vascularity) reflected a higher histological grade (P = 0.025) and had a positive correlation with MVD (r = 0.530, P = 0.001).The retraction pattern and histogram indices of VI provided by 3D ultrasound may be useful in predicting prognostic information about breast cancer.aEuro cent Three-dimensional ultrasound can potentially provide prognostic evaluation of breast cancer.aEuro cent The retraction pattern and hyperechoic ring in the coronal plane suggest good prognosis.aEuro cent The increased intra-tumour vascularization index reflects a higher histological grade.aEuro cent The intra-tumour vascularization index is positively correlated with microvessel density.