A population-based study of the epidemiology and clinical features of methicillin-resistant Staphylococcus aureus infection in Pennsylvania, 2001-2010.
A population-based study of the epidemiology and clinical features of methicillin-resistant Staphylococcus aureus infection in Pennsylvania, 2001-2010.
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DOI：
10.1017/s0950268812001872
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发表时间：
2013-06
影响因子：
4.2
通讯作者：
Schwartz, B. S.
中科院分区：
文献类型：
--
作者：
Casey, J. A.;Cosgrove, S. E.;Stewart, W. F.;Pollak, J.;Schwartz, B. S.
没有美国一般人群为基础的研究特征的流行病学和风险因素，包括皮肤和软组织感染（SSTI），医疗保健相关（HA）和社区相关（CA）耐甲氧西林金黄色葡萄球菌（MRSA）。我们使用宾夕法尼亚州Geisinger诊所的电子健康记录数据估计了9年期间HA和CA-MRSA和SSTI的发病率。在巢式病例对照分析中，MRSA病例与SSTI病例和对照的频率匹配。Logistic回归用于评估风险因素，同时考虑抗生素给药。我们确定了1713例CA和1506例HA MRSA病例以及78216例SSTI病例。从2005年到2009年，CA MRSA的年发病率平均增加了34%，HA-MRSA增加了7%，SSTI增加了4%。年龄、季节、社区社会经济贫困、肥胖、吸烟、既往SSTI和抗生素给药被确定为CA-MRSA的独立危险因素。
No U.S. general population-based study has characterized the epidemiology and risk factors, including skin and soft tissue infection (SSTI), for healthcare-associated (HA) and community-associated (CA) methicillin-resistant Staphylococcus aureus (MRSA). We estimated the incidence of HA and CA-MRSA and SSTI over a 9-year period using electronic health record data from Geisinger Clinic in Pennsylvania. MRSA cases were frequency matched to SSTI cases and controls in a nested case-control analysis. Logistic regression was used to assess risk factors, while accounting for antibiotic administration. We identified 1713 incident CA and 1506 HA MRSA cases and 78216 SSTI cases. On average, from 2005–2009, the annual incidence of CA MRSA increased by 34%, HA-MRSA by 7%, and SSTI by 4%. Age, season, community socioeconomic deprivation, obesity, smoking, prior SSTI, and antibiotic administration were identified as independent risk factors for CA-MRSA.