Sleep deprivation inhibits adult neurogenesis in the hippocampus by elevating glucocorticoids
Sleep deprivation inhibits adult neurogenesis in the hippocampus by elevating glucocorticoids
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DOI：
10.1073/pnas.0608644103
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发表时间：
2006-12-12
影响因子：
11.1
通讯作者：
Gould, Elizabeth
中科院分区：
文献类型：
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作者：
Mirescu, Christian;Peters, Jennifer D.;Gould, Elizabeth
长期睡眠剥夺是有压力的，并与健康和认知表现的不良后果有关。在这里，我们展示了睡眠剥夺在循环皮质酮水平升高的时候抑制成人神经发生。此外，抑制这种荷尔蒙的水平可以防止睡眠不足导致的细胞增殖减少。在慢性睡眠剥夺后，成人神经发生的正常水平的恢复发生在2周的时间内，并涉及新神经元形成的暂时增加。这种补偿性增加与糖皮质激素水平以及正常睡眠模式的恢复无关。总而言之，这些发现表明，尽管睡眠剥夺通过作为应激源抑制成人神经发生，但其补偿性后遗症涉及糖皮质激素非依赖性因素。
Prolonged sleep deprivation is stressful and has been associated with adverse consequences for health and cognitive performance. Here, we show that sleep deprivation inhibits adult neurogenesis at a time when circulating levels of corticosterone are elevated. Moreover, clamping levels of this hormone prevents the sleep deprivation-induced reduction of cell proliferation. The recovery of normal levels of adult neurogenesis after chronic sleep deprivation occurs over a 2-wk period and involves a temporary increase in new neuron formation. This compensatory increase is dissociated from glucocorticoid levels as well as from the restoration of normal sleep patterns. Collectively, these findings suggest that, although sleep deprivation inhibits adult neurogenesis by acting as a stressor, its compensatory aftereffects involve glucocorticoid-independent factors.