Variability in the Apnea-Hypopnea Index and Its Consequences for Diagnosis and Therapy Evaluation
Variability in the Apnea-Hypopnea Index and Its Consequences for Diagnosis and Therapy Evaluation
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DOI：
10.1159/000167790
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发表时间：
2009-01-01
期刊：
影响因子：
3.7
通讯作者：
Naeije, Machiel
中科院分区：
文献类型：
--
作者：
Aarab, Ghizlane;Lobbezoo, Frank;Naeije, Machiel
背景：呼吸暂停低通气指数（AHI）常用于识别阻塞性睡眠呼吸暂停（OSA）和评估治疗。目的：本研究的目的是在10周的时间内确定AHI的变异性，并讨论其诊断和治疗评价的后果。研究方法：15名OSA患者（50.8 ± 11.2岁）接受了4次多导睡眠图（PSG）记录，记录之间的平均间隔为3.3周。结果：四次PSG记录的平均AHI值无差异（p = 0.985）。然而，汇总15名参与者的所有数据，AHI的最小可检测差异为12.8。AHI的个体平均值和标准差（SD）之间的线性回归显示，AHI较高的参与者往往具有较高的SD（p < 0.044）。结论：这些结果表明，在AHI记录相当大的个体内变异性。因此，当AHI位于围绕AHI截止点的截止带之外时，单夜记录只能识别OSA。在评估阻塞性睡眠呼吸暂停综合症治疗时，还应考虑AHI的变异性。在这种情况下，应该注意的是，我们主要想向读者传达的是方法，而不是截止值本身。版权所有（c）2008 S. Karger AG，巴塞尔
Background: The apnea-hypopnea index (AHI) is frequently used to recognize obstructive sleep apnea (OSA) and to evaluate therapy. Objectives: The aim of this study was to determine the AHI variability during a 10-week period, and to discuss its consequences for diagnosis and therapy evaluation. Methods: Fifteen OSA patients (50.8 +/- 11.2 years) underwent four polysomnographic (PSG) recordings, with a mean interval between recordings of 3.3 weeks. Results: No differences were found in the average AHI values of the four PSG recordings ( p = 0.985). Nevertheless, pooling all data of the 15 participants yielded a smallest detectable difference for AHI of 12.8. Linear regression between the individual means and standard deviations (SDs) of AHI showed that participants with a higher AHI tended to have a higher SD (p < 0.044). Conclusions: These results suggest a considerable intra-individual variability in AHI recordings. Hence, a single-night recording can only recognize OSA when the AHI lies outside a cutoff band surrounding the AHI cutoff point. AHI variability should also be taken into account when evaluating OSA therapy. In this context, it should be noted that it is mainly the approach that we would like to convey to the reader and not the cutoff values per se. Copyright (c) 2008 S. Karger AG, Basel