The regulation of translation in reovirus-infected cells.
The regulation of translation in reovirus-infected cells.
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呼肠孤病毒感染细胞中翻译的调节。
DOI：
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发表时间：
1985
影响因子：
3.8
通讯作者：
Luis Carrasco
中科院分区：
文献类型：
--
作者：
A. Muñoz;M. Alonso;Luis Carrasco
通过双重感染实验研究了呼肠孤病毒感染细胞中的翻译调节。在呼肠孤病毒感染的早期和晚期，不同的细胞系能够翻译未加帽的脑心肌炎（EMC）病毒mRNA和加帽的水泡性口炎病毒（VSV）mRNA。这些结果与先前提出的模型不完全一致，在该模型中，在呼肠孤病毒感染的早期阶段，仅翻译加帽的mRNA，而在晚期阶段，细胞被修饰为仅翻译未加帽的mRNA。在双重感染的晚期阶段，EMC病毒和VSV关闭宿主蛋白质合成比呼肠孤病毒翻译更有效的观察结果表明，在这些动物病毒感染的细胞中，对信息歧视因子的竞争可能不参与关闭宿主蛋白质合成。
The regulation of translation in reovirus-infected cells has been investigated by double-infection experiments. Different cell lines were able to translate uncapped encephalomyocarditis (EMC) virus mRNA and capped vesicular stomatitis virus (VSV) mRNAs both early and late during reovirus infection. These results are not fully in agreement with a previously suggested model in which, in the early phase of reovirus infection, only capped mRNAs are translated, whereas in the late phase the cells are modified to translate exclusively uncapped mRNAs. The observations that EMC virus and VSV shut down host protein synthesis more efficiently than reovirus translation in the late phase in double-infections indicate that competition for a message-discriminatory factor may not be involved in the shut-off of host protein synthesis in these animal virus-infected cells.
mRNA 竞争在调节翻译中的作用：mRNA 歧视起始因素的进一步表征。
DOI：
10.1073/pnas.80.3.663
发表时间：
1983
影响因子：
11.1
作者：
Ray,BK;Brendler,TG;Adya,S;Daniels-McQueen,S;Miller,JK;Hershey,JW;Grifo,JA;Merrick,WC;Thach,RE
通讯作者：
Thach,RE