Bronchiolitis in rheumatoid arthritis.
Bronchiolitis in rheumatoid arthritis.
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类风湿性关节炎中的细支气管炎。
DOI：
10.1378/chest.85.5.705
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发表时间：
1984
期刊：
影响因子：
9.6
通讯作者：
A. Vilppula
中科院分区：
文献类型：
--
作者：
A. Lahdensuo;J. Mattila;A. Vilppula
据我们所知，迄今已有 18 名患者报告了与类风湿性关节炎相关的细支气管炎。在某些情况下，青霉胺的使用与细支气管炎的发生密切相关。大多数报告的病例被描述为具有明显的不可逆气道阻塞和恶性通货膨胀。我们描述了一名类风湿性关节炎患者，其呼吸道症状是在黄金疗法期间开始出现的。生理学研究显示，在强制干式肺活量测定研究中，没有病理学发现，存在明显的肺过度充气。开放性肺活检发现轻度肉芽肿性细支气管炎。免疫荧光显微镜显示细支气管壁中含有 IgM 和 IgG 浆细胞。
Bronchiolitis in association with rheumatoid arthritis has been reported, to our knowledge, in 18 patients to date. In some cases use of penicillamine has been strongly associated with the development of bronchiolitis. Most of the reported cases are described as having marked irreversible airways obstruction and hyperinflation. We describe a patient with rheumatoid arthritis whose respiratory tract symptoms began during gold therapy. Physiologic studies showed marked lung hyperinflation without pathologic findings in forced dry spirometric study. On open lung biopsy a mild degree of granulomatous bronchiolitis was found. Immunofluorescent microscopy showed IgM- and IgG-containing plasma cells in the bronchiolar walls.