CIRCADIAN VARIATION IN HUMAN CEREBROSPINAL-FLUID PRODUCTION MEASURED BY MAGNETIC-RESONANCE-IMAGING
CIRCADIAN VARIATION IN HUMAN CEREBROSPINAL-FLUID PRODUCTION MEASURED BY MAGNETIC-RESONANCE-IMAGING
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DOI：
10.1152/ajpregu.1992.262.1.r20
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发表时间：
1992-01-01
影响因子：
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通讯作者：
OWMAN, C
中科院分区：
文献类型：
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作者：
NILSSON, C;STAHLBERG, F;OWMAN, C
磁共振成像的最新进展使脑内脑脊液（CSF）的流动可视化和量化成为可能。通过脑导水管的CSF的净流量被用来测量在24小时内的不同时间在6个正常志愿者的CSF生产。CSF的产生在个体内和个体间差异很大。每个时间间隔内的平均CSF产量显示出明显的昼夜变化趋势，最小产量为最大值的30%（12 +/- 7 ml/h），约为1800 h，夜间峰值产量约为0200 h，为42 +/- 2 ml/h。整个24小时期间的总CSF产生量（计算为所有测量值的平均值）为650 ml（整个组）和630 ml（其中一名志愿者在每个时间间隔重复测量）。
Recent advances in magnetic resonance imaging have made it possible to visualize and quantify flow of cerebrospinal fluid (CSF) in the brain. The net flow of CSF through the cerebral aqueduct was used to measure CSF production in six normal volunteers at different times during a 24-h period. CSF production varied greatly both intra- and interindividually. The average CSF production in each time interval showed a clear tendency to circadian variation, with a minimum production 30% of maximum values (12 +/- 7 ml/h) approximately 1800 h and a nightly peak production approximately 0200 h of 42 +/- 2 ml/h. The total CSF production during the whole 24-h period, calculated as an average of all measurements, was 650 ml for the whole group and 630 ml for repeated measurements in each time interval in one of the volunteers.