Interleukin 22 serum levels are associated with radiographic progression in rheumatoid arthritis
Interleukin 22 serum levels are associated with radiographic progression in rheumatoid arthritis
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DOI：
10.1136/ard.2011.152074
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发表时间：
2011-08-01
影响因子：
27.4
通讯作者：
Skapenko, Alla
中科院分区：
文献类型：
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作者：
Leipe, Jan;Schramm, Markus A.;Skapenko, Alla
目的 研究白细胞介素 22 (IL-22) 在类风湿性关节炎 (RA) 中的作用。方法 测量早期未接受治疗的 RA 患者 (n=49) 和 45 名年龄和性别匹配的健康个体（作为对照）的 IL-22 血清水平。患者在基线时接受临床和放射学评估，并随访 2 年。寻找 IL-22 血清水平与疾病活动参数、血清学标志物、人口因素和糜烂发生率的相关性。通过细胞内流式细胞术研究了外周血 T 细胞产生的 IL-22。结果 49 名 RA 患者中有 24 名患者的 IL-22 水平与健康对照组相比有所升高。在基线时，这些患者中很大一部分（8/24，33%）表现出骨侵蚀，而 IL-22 正常组中只有一名患者（4%）出现骨侵蚀。在 2 年的随访期间，另外 6 名基线 IL-22 升高的患者出现了糜烂。相比之下，尽管治疗方案相似，但 IL-22 水平正常的患者均未出现糜烂。多变量回归分析考虑了其他预测糜烂的参数，例如类风湿因子或抗环瓜氨酸肽抗体的存在以及疾病活动性，表明IL-22基线水平升高与糜烂性RA独立且显着相关。细胞分析表明RA中CD4 T细胞IL-22表达增强。结论 一半RA患者血清中IL-22升高。血清 IL-22 升高可以区分具有不同放射学进展的患者，并表明 IL-22 可能参与 RA 的病理生理学。
Objectives To study the role of interleukin 22 (IL-22) in rheumatoid arthritis (RA).Methods IL-22 serum levels were measured in patients with early, treatment-naive RA (n=49) and in 45 age-and sex-matched healthy individuals as controls. Patients were assessed clinically and radiographically at baseline and followed up for 2 years. Correlations of IL-22 serum levels were sought with parameters of disease activity, serological markers, demographic factors and the incidence of erosions. IL-22 production by peripheral blood T cells was investigated by intracellular fl ow cytometry.Results 24 of 49 patients with RA demonstrated elevated IL-22 levels compared with the range of healthy controls. At baseline, a high percentage of these patients (8/ 24, 33%) demonstrated bone erosions, whereas only one patient (4%) from the group with normal IL-22 had erosions. During the 2 years of follow-up, six additional patients with increased IL-22 at baseline developed erosions. In contrast, none of the patients in whom IL-22 levels were normal developed erosions despite similar treatment regimens. Multivariate regression analysis accounting for other parameters predictive for erosions, such as the presence of rheumatoid factor or anti-cyclic citrullinated peptide antibodies and disease activity, showed that elevated IL-22 baseline levels were independently and signifi cantly associated with erosive RA. Cellular analysis demonstrated enhanced expression of IL-22 from CD4 T cells in RA.Conclusion IL-22 is elevated in the serum of half of the patients with RA. Elevated serum IL-22 allows discrimination between patients with different radiographic progression and indicates a possible involvement of IL-22 in the pathophysiology of RA.