From Retrospective to Prospective: Integrated Value Representation in Frontal Cortex for Predictive Choice Behavior
From Retrospective to Prospective: Integrated Value Representation in Frontal Cortex for Predictive Choice Behavior
复制标题
DOI：
10.1101/2021.12.27.474215
复制
发表时间：
2021-12
期刊：
影响因子：
--
通讯作者：
K. Hamaguchi;Hiromi Takahashi-Aoki;Dai Watanabe
中科院分区：
文献类型：
--
作者：
K. Hamaguchi;Hiromi Takahashi-Aoki;Dai Watanabe
动物必须灵活地估计其行动的价值，以成功地适应不断变化的环境。人们认为大脑从两个不同的来源来评估行动价值，即行动结果历史（回顾性价值）和对环境的了解（前瞻性价值）。这两种对行动价值的不同估计是如何协调起来做出选择的，目前还没有得到很好的理解。本研究表明，当小鼠学习决策任务的状态转换结构时，回顾值和预期值在额叶皮层神经元的准备活动中共同编码。抑制专家小鼠的这种准备活动使它们的行为回到naïve状态。这些结果揭示了整合过去和未来知识以支持预测性决策的神经回路。小鼠额叶皮层的预备活动编码前瞻性价值以支持预测性选择行为。
Animals must flexibly estimate the value of their actions to successfully adapt in a changing environment. The brain is thought to estimate action-value from two different sources, namely the action-outcome history (retrospective value) and the knowledge of the environment (prospective value). How these two different estimates of action-value are reconciled to make a choice is not well understood. Here we show that as a mouse learns the state-transition structure of a decision-making task, retrospective and prospective values become jointly encoded in the preparatory activity of neurons in the frontal cortex. Suppressing this preparatory activity in expert mice returned their behavior to a naïve state. These results reveal the neural circuit that integrates knowledge about the past and future to support predictive decision-making. One-Sentence Summary Preparatory activity in the mouse frontal cortex encodes prospective value to support predictive choice behavior.