Human immunity to the meningococcus. I. The role of humoral antibodies.
Human immunity to the meningococcus. I. The role of humoral antibodies.
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DOI：
10.1084/jem.129.6.1307
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发表时间：
1969-06-01
期刊：
影响因子：
--
通讯作者：
Artenstein MS
中科院分区：
文献类型：
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作者：
Goldschneider I;Gotschlich EC;Artenstein MS
对系统性脑膜炎双球菌疾病的易感性与对脑膜炎双球菌致病菌株的体液抗体的选择性缺乏有关。在一项关于美国脑膜炎双球菌脑膜炎特定年龄发病率的研究中，发现具有血清杀菌活性的个体对A、B和C群脑膜炎双球菌的比例与疾病发病率成反比关系。杀菌活性的流行率在出生时和成人中最高，而在6至24个月大的婴儿中最低。用血清杀菌活性和间接免疫荧光法检测54例新兵脑膜炎球菌病准病例中51例血清中抗同源和异源致病脑膜炎双球菌抗体。然而，这种血清可以支持纯化的人丙种球蛋白(科恩部分II)的杀菌活性，这些人可以对脑膜炎双球菌感染做出免疫反应。这意味着易感人群缺乏抗脑膜炎双球菌抗体，因为他们过去没有大量接触过脑膜炎双球菌抗原。在新兵中暴发C组脑膜炎期间，缺乏致病性脑膜炎双球菌杀菌抗体的人的命运被决定。疾病的发病率被发现主要与易感人群接触致病菌株的发病率有关。虽然81.5%的假定易感人群获得了脑膜炎双球菌菌株，但只有24.1%的人获得了与流行的致病菌株相似的有机体。在暴露的易感人群中，38.5%的人发展为系统性脑膜炎双球菌疾病。
Susceptibility to systemic meningococcal disease is related to a selective deficiency of humoral antibodies to pathogenic strains of meningococci. In a study of the age-specific incidence of meningococcal meningitis in the United States, it was found that the proportion of individuals with serum bactericidal activity to meningococci of serogroups A, B, and C was reciprocally related to the incidence of disease. The prevalence of bactericidal activity was highest at birth and among adults, and lowest in infants between 6 and 24 months of age. Sera from 51 of 54 prospective cases of meningococcal disease among military recruits were deficient in antibodies to homologous and heterologous strains of pathogenic meningococci as determined by serum bactericidal activity and indirect immunofluorescence. Such sera, however, could support the bactericidal activity of purified human gamma globulin (Cohn fraction II), and such individuals could respond immunologically to infection with meningococci. The implication is that susceptible persons are deficient in antimeningococcal antibodies because they have not received significant exposure to meningococcal antigens in the past. The fate of individuals who lack bactericidal antibodies to pathogenic meningococci was determined during an outbreak of group C meningitis among military recruits. The incidence of disease was found to be primarily associated with the incidence of exposure of susceptibles to the pathogenic strains. Whereas 81.5% of the presumed susceptibles acquired a meningococcal strain, only 24.1% acquired an organism similar to the prevalent disease-producing strains. Of the exposed susceptibles, 38.5% developed systemic meningococcal disease.