Binaural specialisation in human auditory cortex:: an fMRI investigation of interaural correlation sensitivity
Binaural specialisation in human auditory cortex:: an fMRI investigation of interaural correlation sensitivity
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DOI：
10.1016/j.neuroimage.2003.07.026
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发表时间：
2003-11-01
期刊：
影响因子：
5.7
通讯作者：
Summerfield, AQ
中科院分区：
文献类型：
--
作者：
Budd, TW;Hall, DA;Summerfield, AQ
听众对声音的耳间相关性（IAC）的敏感性在双耳听力的几种现象中发挥着重要作用。虽然在动物的神经生理学研究和人类的心理物理学研究中已经对IAC进行了广泛的研究，但对人类对IAC敏感性的神经基础知之甚少。本研究采用功能磁共振成像测量血氧水平依赖（BOLD）的活动，在人类听众的听觉脑干和皮层结构在带通噪声刺激，IAC之间的变化系统。刺激引起下丘，内侧膝状体和听觉皮层显着的双边激活。BOLD活动与IAC之间存在显著的正相关关系，IAC仅限于位于Heschl回外侧两侧的初级听觉皮层的一个不同的子区域。与已发表的解剖学数据的比较表明，这方面也可能是不同的cytoarchitecturally。IAC接近1的水平之间的激活差异大于接近0的水平之间的激活差异。这种反应模式是定性兼容与以前的措施的心理物理和神经生理的敏感性IAC。(C)2003年爱思唯尔公司All rights reserved.
A listener's sensitivity to the interaural correlation (IAC) of sound plays an important role in several phenomena in binaural hearing. Although IAC has been examined extensively in neurophysiological studies in animals and in psychophysical studies in humans, little is known about the neural basis of sensitivity to IAC in humans. The present study employed functional magnetic resonance imaging to measure blood oxygen level-dependent (BOLD) activity in auditory brainstem and cortical structures in human listeners during presentation of band-pass noise stimuli between which IAC was varied systematically. The stimuli evoked significant bilateral activation in the inferior colliculus, medial geniculate body, and auditory cortex. There was a significant positive relationship between BOLD activity and IAC which was confined to a distinct subregion of primary auditory cortex located bilaterally at the lateral extent of Heschl's gyrus. Comparison with published anatomical data indicated that this area may also be cytoarchitecturally distinct. Larger differences in activation were found between levels of IAC near unity than between levels near zero. This response pattern is qualitatively compatible with previous measures of psychophysical and neurophysiological sensitivity to IAC. (C) 2003 Elsevier Inc. All rights reserved.