Acetylcholine promotes progesterone-induced maturation of Xenopus oocytes.

Acetylcholine promotes progesterone-induced maturation of Xenopus oocytes.
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乙酰胆碱促进黄体酮诱导的非洲爪蟾卵母细胞成熟。

DOI:
10.1002/jez.1402300117
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发表时间:
1984
期刊:
The Journal of experimental zoology
影响因子:
--
通讯作者:
Y. Oron
Y. Oron
中科院分区:
--
文献类型:
--
作者:
N. Dascal;R. Yekuel;Y. Oron

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黄体酮诱导的卵泡封闭和裸露的非洲爪蟾卵母细胞的成熟因同时暴露于乙酰胆碱而显着缩短。乙酰胆碱对成熟的促进作用被特异性毒蕈碱拮抗剂阿托品阻断。乙酰胆碱的作用是剂量依赖性的,并且神经递质在非常低的浓度下就有效。黄体酮逐渐降低非洲虎卵母细胞对乙酰胆碱的电生理反应,这种反应在接近生发囊泡破裂时完全消失。单独使用黄体酮不会引起任何电生理反应。乙酰胆碱对卵母细胞成熟的体外作用可能反映了胆碱能系统对体内成熟过程的生理影响。
Progesterone-induced maturation of follicle-enclosed and denuded Xenopus laevis oocytes was significantly shortened by a concomitant exposure to acetylcholine. The promotion of maturation by acetylcholine was blocked by the specific muscarinic antagonist atropine. The action of acetylcholine was dose dependent, and the neurotransmitter was effective at very low concentrations. Progesterone progressively reduced the electrophysiological responses of X. laevis oocytes to acetylcholine, which completely disappeared close to the time of germinal vesicle breakdown. Progesterone alone did not elicit any electrophysiological responses. The in vitro effect of acetylcholine on oocyte maturation might reflect a physiological influence of the cholinergic system on an in vivo maturation process.
DOI: 10.1016/s0021-9258(19)69173-8
发表时间: 1981-06
期刊: The Journal of biological chemistry
影响因子: --
作者:
S. E. Sadler;J. Maller
通讯作者: S. E. Sadler;J. Maller
黄体酮和 2,5-双脱氧腺苷对非洲爪蟾卵母细胞腺苷酸环化酶的抑制与鸟嘌呤核苷酸交换减慢有关。
DOI: --
发表时间: 1983
期刊: The Journal of biological chemistry
影响因子: --
作者:
Sadler,SE;Maller,JL
通讯作者: Maller,JL
Ca2 和环核苷酸在黄体酮启动两栖类卵母细胞减数分裂中的作用。
DOI: 10.1016/0024-3205(81)90513-0
发表时间: 1981
期刊: Life sciences
影响因子: 6.1
作者:
Morrill,GA;Ziegler,D;Kostellow,AB
通讯作者: Kostellow,AB