Calix[8]arene functionalized single-walled carbon nanohorns for dual-signalling electrochemical sensing of aconitine based on competitive host-guest recognition
Calix[8]arene functionalized single-walled carbon nanohorns for dual-signalling electrochemical sensing of aconitine based on competitive host-guest recognition
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Calix[8]芳烃功能化单壁碳纳米角用于基于竞争性主客体识别的乌头碱双信号电化学传感
DOI：
10.1016/j.bios.2016.04.079
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发表时间：
2016
影响因子：
12.6
通讯作者：
Li Can-Peng
中科院分区：
文献类型：
--
作者：
Yang Long;Ran Xin;Cai Le;Li Yucong;Zhao Hui;Li Can-Peng
以亚甲基蓝（MB）和磺化杯[8]芳烃修饰的单壁碳纳米角（SCX 8-SWCNHs）为“报告分子对”，建立了基于主客体竞争相互作用的乌头碱双信号电化学研究方法.当乌头碱存在于所形成的SCX 8-SWCNHs·MB复合物中时，MB分子被乌头碱置换。这导致MB的氧化峰电流降低和乌头碱的氧化峰的出现，并且这些信号的变化与乌头碱的浓度呈线性相关。乌头碱的线性范围为1.00-10.00 μM，检出限为0.18 μM（S/N=3）。该方法可用于血清中乌头碱的测定。这种双信号传感器可以提供更灵敏的目标识别，并将在乌头碱的灵敏和选择性的电化学检测中有重要的应用。
A dual-signalling electrochemical approach has been developed towards aconitine based on competitive host–guest interaction by selecting methylene blue (MB) and p-sulfonated calix[8]arene functionalized single-walled carbon nanohorns (SCX8–SWCNHs) as the “reporter pair”. Upon the presence of aconitine to the performed SCX8–SWCNHs·MB complex, the MB molecules are displaced by aconitine. This results in a decreased oxidation peak current of MB and the appearance of an oxidation peak of aconitine, and the changes of these signals correlate linearly with the concentration of aconitine. A linear response range of 1.00–10.00 μM for aconitine with a low detection limit of 0.18 μM (S/N=3) was obtained by using the proposed method. This method could be successfully utilized to detect aconitine in serum samples. This dual-signalling sensor can provide more sensitive target recognition and will have important applications in the sensitive and selective electrochemical detection of aconitine.