Cardiomyocyte autophagy and cancer chemotherapy.
Cardiomyocyte autophagy and cancer chemotherapy.
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DOI：
10.1016/j.yjmcc.2013.11.007
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发表时间：
2014-06
影响因子：
5
通讯作者：
Hill, Joseph A.
中科院分区：
文献类型：
--
作者：
Li, Dan L.;Hill, Joseph A.
自噬是一种在进化上保守的细胞自食过程，在心脏生理学中起着至关重要的作用。心肌细胞自噬的紊乱会导致多种心脏疾病的发病机制，其中许多疾病最终会导致心力衰竭。随着癌症化疗的最新进展以及癌症生存率的相应提高，药物对心脏的毒性变得更加重要。由于许多重要的细胞通路对肿瘤细胞和心脏细胞的生存都至关重要，因此针对这些通路的治疗在两种组织中都会产生影响也就不足为奇了。目前对于化疗环境下心肌细胞自噬（一种对压力的重要细胞反应）知之甚少，但初步证据表明其具有重要且依赖于环境的作用。剖析自噬在“肿瘤心脏病学”中的作用可能会深入了解心肌病的潜在机制，并可能导致保护心肌免受化疗诱导损伤的新方法。
Autophagy, an evolutionally conserved process of controlled cellular cannibalization, plays a vital role in cardiac physiology. Perturbations in cardiomyocyte autophagy contribute to the pathogenesis of a wide range of cardiac diseases, many of which culminate in heart failure. With recent advances in cancer chemotherapy and consequent improvements in cancer survival, drug-induced toxicity to the heart has assumed greater importance. As a number of prominent cellular pathways are critical to the survival of both tumor cells and heart cells, it comes as little surprise that therapies targeting those pathways have consequences in both tissues. Little is known presently about cardiomyocyte autophagy, a prominent cellular response to stress, in the setting of chemotherapy, but preliminary evidence suggests an important and context-dependent role. Dissecting the role of autophagy in “onco-cardiology” will likely yield insights into mechanisms underlying cardiomyopathy and may lead to novel means to protect the myocardium from chemotherapy-induced injury.
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